Department of Medical Laboratories Techniques, Al-Mustaqbal University College, Hilla, Babylon, 51001, Iraq.
Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq.
Mol Biotechnol. 2024 Oct;66(10):2679-2696. doi: 10.1007/s12033-023-00873-1. Epub 2023 Sep 28.
A monster called cancer is still one of the most challenging human problems and one of the leading causes of death in the world. Different types of treatment methods are used for cancer therapy; however, there are challenges such as high cost and harmful side effects in using these methods. Recent years have witnessed a surge in the development of therapeutic peptides for a wide range of diseases, notably cancer. Peptides are preferred over antibiotics, radiation therapy, and chemotherapy in the treatment of cancer due to a number of aspects, including flexibility, easy modification, low immunogenicity, and inexpensive cost of production. The use of therapeutic peptides in cancer treatment is a novel and intriguing strategy. These peptides provide excellent prospects for targeted drug delivery because of their high selectivity, specificity, small dimensions, good biocompatibility, and simplicity of modification. Target specificity and minimal toxicity are benefits of therapeutic peptides. Additionally, peptides can be used to design antigens or adjuvants for vaccine development. Here, types of therapeutic peptides for cancer therapy will be discussed, such as peptide-based cancer vaccines and tumor-targeting peptides (TTP) and cell-penetrating peptides (CPP).
癌症这种怪物仍然是人类面临的最具挑战性的问题之一，也是世界上主要的死亡原因之一。癌症治疗采用了多种不同类型的治疗方法；然而，这些方法在使用中存在成本高和副作用大等挑战。近年来，治疗各种疾病的治疗性肽的开发如雨后春笋般涌现，尤其是癌症。与抗生素、放射疗法和化学疗法相比，肽在癌症治疗中具有灵活性、易于修饰、低免疫原性和生产成本低廉等诸多优势，因此更受青睐。治疗性肽在癌症治疗中的应用是一种新颖而有趣的策略。由于其高选择性、特异性、小尺寸、良好的生物相容性和易于修饰等特点，这些肽为靶向药物输送提供了极好的前景。治疗性肽具有靶向特异性和最小毒性等优点。此外，肽可用于设计抗原或佐剂用于疫苗开发。在这里，将讨论用于癌症治疗的各种治疗性肽，如基于肽的癌症疫苗和肿瘤靶向肽（TTP）和细胞穿透肽（CPP）。
