Chao W R, Helmes C T, Dawson M I
Cancer Lett. 1985 Oct;29(1):43-8. doi: 10.1016/0304-3835(85)90121-1.
Linear regression analysis of the dose levels of a series of retinoids required ornithine decarboxylase (ODC) induction by 50% indicated that there was no significant difference in inhibitory activity between CD-1 and Sencar mice (r = 0.9699; P less than 0.001). The ID50 values (nmol) found were as follows: retinoic acid (0.20, CD-1; 0.29, Sencar); 13-cis-retinoic acid (1.4, CD-1; 1.9, Sencar); 4-[2-(5,6,7,8-tetrahydro-5,5,8, 8-tetramethyl-2-naphthalenyl)-1E-propenyl]benzoic acid (0.04, CD-1; 0.03; Sencar); 2-[1-(4-carboxyphenyl)-1E-propeny-2-yl]-4,5,6,7-tetrahydro-4, 4-dimethylbenzothiophene (0.08, CD-1; 0.14, Sencar); 2-[1-(4-carboxyphenyl)-1E-propen-2-yl]3, 4-dihydro-4,4-dimethyl-2H-1-benzothiopyran (0.56, CD-1; 0.70, Sencar); 6-(5,6,7,8-tetrahydro-5,5,8, 8-tetramethyl-2-naphthalenyl)-2-naphthalenecarboxylic acid (1.0, CD-1; 0.90, Sencar).
对一系列维甲酸剂量水平进行线性回归分析，这些维甲酸可使鸟氨酸脱羧酶（ODC）诱导率降低50%，结果表明CD - 1小鼠和Sencar小鼠在抑制活性上无显著差异（r = 0.9699；P小于0.001）。所测得的半数抑制剂量（ID50值，单位为纳摩尔）如下：维甲酸（CD - 1小鼠为0.20；Sencar小鼠为0.29）；13 - 顺式维甲酸（CD - 1小鼠为1.4；Sencar小鼠为1.9）；4 - [2 - (5,6,7,8 - 四氢 - 5,5,8,8 - 四甲基 - 2 - 萘基) - 1E - 丙烯基]苯甲酸（CD - 1小鼠为0.04；Sencar小鼠为0.03）；2 - [1 - (4 - 羧基苯基) - 1E - 丙烯 - 2 - 基] - 4,5,6,7 - 四氢 - 4,4 - 二甲基苯并噻吩（CD - 1小鼠为0.08；Sencar小鼠为0.14）；2 - [1 - (4 - 羧基苯基) - 1E - 丙烯 - 2 - 基] - 3,4 - 二氢 - 4,4 - 二甲基 - 2H - 1 - 苯并噻喃（CD - 1小鼠为0.56；Sencar小鼠为0.70）；6 - (5,6,7,8 - 四氢 - 5,5,8,8 - 四甲基 - 2 - 萘基) - 2 - 萘甲酸（CD - 1小鼠为1.0；Sencar小鼠为0.90）。
