Egodage Tanya, Patel Purvi Pravinchandra
Surgery, Cooper University Health Care, Camden, New Jersey, USA.
Department of Surgery, Loyola University Chicago, Maywood, Illinois, USA.
Trauma Surg Acute Care Open. 2024 Apr 15;9(Suppl 2):e001382. doi: 10.1136/tsaco-2024-001382. eCollection 2024.
Traumatic brain injury (TBI) confers significant morbidity and mortality, and is a pathology often encountered by trauma surgeons. Several recent trials have evaluated management protocols of patients with severe TBI. The Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II trial (BOOST-II) evaluated efficacy and feasibility of brain oxygen measurement in severe TBI. BOOST phase 3 trial (BOOST-3) and two ongoing trials look to measure functional outcomes in this population. Furthermore, middle meningeal artery embolization has now become standard therapy for adult patients with chronic subdural hematoma (SDH) and has increasing popularity in those with recurrent SDH as an alternative to surgical intervention. In this manuscript, we review the literature, ongoing trials, and discuss current updates in the management of TBI.
创伤性脑损伤(TBI)会导致严重的发病率和死亡率,是创伤外科医生经常遇到的一种病理情况。最近的几项试验评估了重度TBI患者的管理方案。重度创伤性脑损伤二期脑氧优化试验(BOOST-II)评估了重度TBI患者脑氧测量的有效性和可行性。BOOST三期试验(BOOST-3)和两项正在进行的试验旨在测量该人群的功能结局。此外,脑膜中动脉栓塞现已成为成年慢性硬膜下血肿(SDH)患者的标准治疗方法,并且在复发性SDH患者中作为手术干预的替代方法越来越受欢迎。在本手稿中,我们回顾了相关文献、正在进行的试验,并讨论了TBI管理方面的当前进展。