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贝伐单抗诱发转移性结肠癌患者发生皮肤型红斑狼疮:一例报告

Bevacizumab-Induced Cutaneous Lupus Erythematosus in a Patient With Metastatic Colon Carcinoma: A Case Report.

作者信息

Ashish Sethi, Raj Moses, Zhuang Eric

机构信息

Infectious Disease, University of Missouri Kansas City School of Medicine, Kansas City, USA.

Hematology and Oncology, Allegheny Health Network, Pittsburgh, USA.

出版信息

Cureus. 2024 Mar 20;16(3):e56559. doi: 10.7759/cureus.56559. eCollection 2024 Mar.

Abstract

Bevacizumab, an anti-vascular epidermal growth factor inhibitor, is approved for the treatment of various cancers. Hypertension, gastrointestinal perforation, bleeding manifestations, impaired wound healing, and cerebrovascular accidents are common side effects associated with the monoclonal antibody. Uncommon cutaneous reactions like exfoliative dermatitis associated with bevacizumab have been documented in the medical literature. We present an unusual case of bevacizumab-induced cutaneous lupus in a patient with metastatic colon cancer that started resolving after discontinuing chemotherapy. Timely intervention was key in preventing the progression of this chemotherapy-induced cutaneous lupus.

摘要

贝伐单抗是一种抗血管内皮生长因子抑制剂,已被批准用于治疗多种癌症。高血压、胃肠道穿孔、出血表现、伤口愈合受损和脑血管意外是与这种单克隆抗体相关的常见副作用。医学文献中已记录了与贝伐单抗相关的罕见皮肤反应,如剥脱性皮炎。我们报告了一例转移性结肠癌患者发生贝伐单抗诱发的皮肤狼疮的不寻常病例,该病例在停止化疗后开始缓解。及时干预是预防这种化疗诱发的皮肤狼疮进展的关键。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fee6/11028020/7f65c5d69096/cureus-0016-00000056559-i01.jpg

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