Shakhbazova Anastasia, Marsch Amanda F
Department of Dermatology, University of California San Diego, La Jolla, CA.
Dermatol Online J. 2019 Nov 15;25(11):13030/qt3nw0p7hn.
Drug-induced subacute cutaneous lupus erythematosus (SCLE) is the most common subtype of drug-induced systemic lupus erythematosus and has been associated with more than 100 drugs. It presents weeks to months after initiation of the culprit medication. The eruption is typically in a photodistribution and it is marked by positive serology to anti-Ro (SSA) antibody. Systemic 5-fluorouracil (5-FU) is a less-common culprit of drug-induced SCLE and its occurrence is likely dependent on exposure to ultraviolet light. Herein, we present a review of drug-induced lupus induced by the pyrimidine analog, 5-FU, and its prodrugs, capecitabine and uracil-tegafur. The search was carried out using the following terms: (PubMed: keywords included drug-induced lupus, 5-fluorouracil, subacute cutaneous lupus erythematosus, capecitabine, uracil-tegafur, discoid lupus, systemic lupus erythematosus).
药物性亚急性皮肤型红斑狼疮（SCLE）是药物性系统性红斑狼疮最常见的亚型，与100多种药物有关。它在引发药物开始使用数周或数月后出现。皮疹通常呈光暴露分布，抗Ro（SSA）抗体血清学检查呈阳性。全身性5-氟尿嘧啶（5-FU）是药物性SCLE较少见的致病因素，其发生可能与紫外线暴露有关。在此，我们对由嘧啶类似物5-FU及其前体药物卡培他滨和替加氟尿嘧啶引起的药物性狼疮进行综述。检索使用了以下术语：（PubMed：关键词包括药物性狼疮、5-氟尿嘧啶、亚急性皮肤型红斑狼疮、卡培他滨、替加氟尿嘧啶、盘状狼疮、系统性红斑狼疮）
