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着色性干皮病C组和干扰素-γ在非小细胞肺癌中的临床预后意义

Clinical prognostic significance of xeroderma pigmentosum group C and IFN‑γ in non‑small cell lung cancer.

作者信息

Wang Yongming, Wang Weiyu, Wang Huaijie, Qin Liya, Zhang Meijia, Zhang Yong, Wang Yubing, Hao Changcheng, Qu Meihua, Wang Gongchao

机构信息

Department of Thoracic Surgery, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China.

Department of Thoracic Surgery, Translational Medical Center, Weifang Second People's Hospital (Weifang Respiratory Disease Hospital), Weifang, Shandong 261041, P.R. China.

出版信息

Oncol Lett. 2024 Apr 9;27(6):259. doi: 10.3892/ol.2024.14392. eCollection 2024 Jun.

DOI:10.3892/ol.2024.14392
PMID:38646492
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11027110/
Abstract

Lung cancer is the most common cancer in the world due to its high incidence and recurrence. Genetic instability is one of the main factors leading to its occurrence, development and poor prognosis. Decreased xeroderma pigmentosum group C (XPC) expression notably enhances the stem cell properties of lung cancer cells and increases their proliferation and migration. Additionally, patients with lung cancer and low XPC expression had a poor prognosis. The purpose of the present study was to analyze the effect of XPC and IFN-γ on the clinical prognosis of patients with non-small cell lung cancer (NSCLC). Lung adenocarcinoma specimens were collected from a total of 140 patients with NSCLC. Additionally, from these 140 patients, 48 paracarcinoma tissue specimens were also collected, which were later used to construct tissue microarrays. The expression of XPC and IFN-γ in cancer tissues and in paraneoplastic tissues was detected using immunohistochemistry. The prognosis and overall survival of patients were determined through telephone follow-up. The results showed a positive correlation between expression of XPC and IFN-γ in NSCLC. Additionally, high expression of both markers was associated with a favorable prognosis in patients with NSCLC. The aforementioned findings suggest that the expression of XPC and IFN-γ has prognostic value in clinical practice and is expected to become a marker for clinical application.

摘要

由于肺癌的高发病率和高复发率，它是世界上最常见的癌症。基因不稳定是导致其发生、发展和预后不良的主要因素之一。着色性干皮病C组（XPC）表达降低显著增强了肺癌细胞的干细胞特性，并增加了其增殖和迁移能力。此外，XPC表达低的肺癌患者预后较差。本研究的目的是分析XPC和干扰素-γ（IFN-γ）对非小细胞肺癌（NSCLC）患者临床预后的影响。共收集了140例NSCLC患者的肺腺癌标本。此外，从这140例患者中还收集了48例癌旁组织标本，随后用于构建组织芯片。采用免疫组织化学法检测癌组织和癌旁组织中XPC和IFN-γ的表达。通过电话随访确定患者的预后和总生存期。结果显示，NSCLC中XPC和IFN-γ的表达呈正相关。此外，两种标志物的高表达与NSCLC患者的良好预后相关。上述研究结果表明，XPC和IFN-γ的表达在临床实践中具有预后价值，有望成为临床应用的标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cde/11027110/28c556d420e9/ol-27-06-14392-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cde/11027110/0cd1266b387d/ol-27-06-14392-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cde/11027110/22ec88b1dd6f/ol-27-06-14392-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cde/11027110/9fe28e0a111e/ol-27-06-14392-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cde/11027110/802640d499d1/ol-27-06-14392-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cde/11027110/28c556d420e9/ol-27-06-14392-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cde/11027110/0cd1266b387d/ol-27-06-14392-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cde/11027110/22ec88b1dd6f/ol-27-06-14392-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cde/11027110/9fe28e0a111e/ol-27-06-14392-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cde/11027110/802640d499d1/ol-27-06-14392-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9cde/11027110/28c556d420e9/ol-27-06-14392-g04.jpg

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本文引用的文献

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着色性干皮病C互补组（XPC）：在非皮肤恶性肿瘤中的新作用
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