Takahashi Reo, Isshiki Shin-Nosuke, Hakozaki Mayuka, Kanno Yuko, Uesugi Shota, Koseki Takuya, Shiono Yoshihito
Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Japan.
Iwate Biotechnology Research Center, Kitakami, Japan.
Nat Prod Res. 2024 Apr 22:1-8. doi: 10.1080/14786419.2024.2342557.
Two novel aromatic polyketides and and five known compounds, (4,10)-talaroflavone (), altenuene (), isoaltenuene (), alternariol (), and altenusin (), were isolated from an endophytic strain of SI-694. The structures of the new compounds, including their absolute configurations, were elucidated by NMR, IR, UV, and ECD spectroscopies, and the phytotoxicities of the isolated compounds were also evaluated. Altenusin () showed moderate cytotoxicity against HL-60 cells, with an IC of 6.65 µM, whereas , , and were phytotoxic against , L., (L.) Scop. and .
从内生菌株SI - 694中分离出两种新型芳香聚酮化合物以及和五种已知化合物，即(4,10)-塔拉黄酮()、互隔交链孢酚()、异互隔交链孢酚()、互隔交链孢酚单甲醚()和交链孢菌酚()。通过核磁共振、红外、紫外和圆二色光谱对新化合物的结构包括其绝对构型进行了阐明，并且还评估了分离出的化合物的植物毒性。交链孢菌酚()对HL - 60细胞显示出中等细胞毒性，半数抑制浓度为6.65 µM，而、和对、L.、(L.) Scop. 和具有植物毒性。
