Department of Health and Rehabilitation Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia -
Department of Health and Rehabilitation Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
Eur J Phys Rehabil Med. 2024 Jun;60(3):496-504. doi: 10.23736/S1973-9087.24.08034-1. Epub 2024 Apr 22.
The primary aim of this study was to longitudinally examine the impact of diabetes mellitus (DM) on physical performance measures including Gait Speed and Chair Stand tests over 8 years of follow-up in people with or at risk of knee osteoarthritis (OA).
A prospective longitudinal study.
Multisite community based.
This study included participants with or at risk of knee OA aged from 45 to 79 years from the Osteoarthritis Initiative from baseline to 96 months follow-up.
The participants performed physical performance measures using a 20 m Walk Test for Gait Speed and 5 Times Sit To Stand for repeated chair stand test time at baseline and during follow-up visits. Participants were asked about the presence of diabetes mellitus (DM) at baseline and categorized into with or without DM. Generalized estimating equations were utilized with 2 models, one for DM and Gait Speed and the other for DM and Repeated Chair Stand Test after controlling for covariates including age, sex, education, Body Mass Index (BMI), depressive symptoms, physical activity level, baseline number of comorbidities, and baseline Kellgren and Lawrence grades for OA grading for each knee.
A total of 4796 participants were included and categorized into those with DM (N.=362) and without DM (N.=4311) at baseline. Participants with DM at baseline showed significantly declined gait speed (B=-0.048, 95% Confidence Interval [95% CI]: [-0.07, -0.02], P<0.001) and significantly an increased time for repeated chair stand test (B=0.49, 95% CI: [0.08, 0.89], P=0.018) over time when compared to those without DM at baseline, after controlling for covariates.
DM was associated with negative impact on Gait Speed and Repeated Chair Stand Test time in individuals with or at risk of knee OA. Individuals with knee OA and diabetes who exhibit declining physical performance measures are at risk of functional dependence, reduced quality of life, and complex rehabilitation requirements.
本研究的主要目的是在 8 年的随访中，纵向研究糖尿病（DM）对包括步态速度和坐立试验在内的身体表现测量的影响，参与者为有或处于膝关节骨关节炎（OA）风险中的人群。
前瞻性纵向研究。
基于社区的多站点。
这项研究包括来自骨关节炎倡议的基线至 96 个月随访的年龄在 45 至 79 岁之间的有或处于膝关节 OA 风险中的参与者。
参与者在基线和随访期间使用 20 米步行测试进行步态速度测试，使用 5 次坐立测试进行重复坐立测试时间。在基线时询问参与者是否患有糖尿病（DM），并根据是否患有 DM 将其分为 DM 组和非 DM 组。在控制年龄、性别、教育程度、体重指数（BMI）、抑郁症状、身体活动水平、基线共病数量和基线每个膝关节的 Kellgren 和 Lawrence OA 分级等协变量后，利用广义估计方程（GEE）进行了 2 个模型的分析，一个是 DM 和步态速度，另一个是 DM 和重复坐立试验。
共有 4796 名参与者被纳入研究，并根据基线时是否患有 DM（n=362）和非 DM（n=4311）进行分类。与基线时无 DM 的参与者相比，基线时患有 DM 的参与者步态速度明显下降（B=-0.048，95%置信区间[95%CI]：[-0.07，-0.02]，P<0.001），且重复坐立试验的时间明显增加（B=0.49，95%CI：[0.08，0.89]，P=0.018），这是在控制了协变量后的结果。
DM 与有或处于膝关节 OA 风险中的个体的步态速度和重复坐立试验时间的负面影响有关。患有膝关节 OA 和糖尿病且身体表现测量下降的个体有功能依赖、生活质量降低和复杂康复需求的风险。
