Department of Health and Rehabilitation Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
Medicina (Kaunas). 2024 Aug 12;60(8):1305. doi: 10.3390/medicina60081305.
: This study aimed to examine the longitudinal impact of multisite musculoskeletal pain on physical and mental health-related quality of life among individuals with or at risk of knee osteoarthritis. : This study is a prospective longitudinal design over 8 years of follow-up. Data from 4796 participants aged between 45 and 79 years were acquired from the Osteoarthritis Initiative. Based on self-reported physician-diagnosed osteoarthritis and grade ≥2 in either knee using Kellgren and Lawrence grade at baseline, individuals at risk were classified as those who did not have knee osteoarthritis at baseline but could develop osteoarthritis throughout the study. Physical and mental components of health-related quality were assessed over an 8-year follow-up period using both knee injury and osteoarthritis outcome scores and the 12-item Short-Form Health Survey. Multisite pain was examined using a self-reported questionnaire for 20 sites. Two separate generalized estimating equations modeled with a linear regression analysis were utilized. : The results showed that participants with one painful site (Beta [B] = -0.92, = 0.01), two painful sites (B = -1.94, < 0.001), and multisite pain (≥3 painful sites) (B = -4.68, < 0.001) were significantly associated with declined physical health-related quality of life over time when compared to those with no painful site at baseline after adjustments for covariates. However, there was no significant association with declined mental health-related quality of life over time. : This study revealed that baseline multisite musculoskeletal pain was linked to declining physical and knee injury and osteoarthritis outcome score quality of life among individuals with or at risk of knee osteoarthritis. Moreover, having baseline multisite pain and two painful sites were associated with a decline in physical and knee injury and osteoarthritis outcome score quality of life, while mental health-related quality of life did not show a significant association with multisite pain. Therefore, it is imperative for primary healthcare settings to prioritize the assessment of multisite musculoskeletal pain and develop interventions aimed at preserving and enhancing physical health-related quality of life in people with or at risk of osteoarthritis.
本研究旨在探讨多部位肌肉骨骼疼痛对膝骨关节炎患者或高危人群的身心健康相关生活质量的纵向影响。
本研究为前瞻性纵向设计，随访时间为 8 年。数据来自骨关节炎倡议的 4796 名 45 至 79 岁的参与者。根据自我报告的医生诊断的骨关节炎和基线时使用 Kellgren 和 Lawrence 分级≥2 的任何一个膝关节，将高危人群定义为基线时没有膝关节骨关节炎但在整个研究过程中可能发展为骨关节炎的人群。在 8 年的随访期间，使用膝关节损伤和骨关节炎结局评分以及 12 项简明健康调查，评估身心健康相关的物理和心理成分。使用自我报告的问卷检查 20 个部位的多部位疼痛。使用线性回归分析，采用两个单独的广义估计方程进行建模。
结果显示，与基线时无疼痛部位的参与者相比，有一个疼痛部位（B=-0.92， =0.01）、两个疼痛部位（B=-1.94， <0.001）和多部位疼痛（≥3 个疼痛部位）（B=-4.68， <0.001）的参与者随着时间的推移，其身体健康相关的生活质量显著下降，调整协变量后。然而，与时间推移相关的心理健康相关生活质量没有显著下降。
本研究表明，基线多部位肌肉骨骼疼痛与膝骨关节炎患者或高危人群的身体和膝关节损伤及骨关节炎结局评分相关生活质量下降有关。此外，基线多部位疼痛和两个疼痛部位与身体和膝关节损伤及骨关节炎结局评分相关生活质量下降有关，而心理健康相关生活质量与多部位疼痛无显著相关性。因此，初级保健机构有必要优先评估多部位肌肉骨骼疼痛，并制定旨在维持和提高有或高危骨关节炎人群身心健康相关生活质量的干预措施。
