Janunger K G, Lindgren J, Sipponen P, Domellöf L
Scand J Gastroenterol. 1979;14(5):555-60. doi: 10.3109/00365527909181389.
Carcinoembryonic antigen (CEA) was studied by the three-layer bridge immunoperoxidase technique in gastric biopsy specimens taken from 49 patients, 13--20 years after partial gastrectomy. Routine histological examination revealed various degrees of chronic atrophic gastritis in all patients. A positive CEA reaction was found in 6 out of 9 with malignant or premalignant mucosal changes and in 4 out of 40 without these changes. In two cases of carcinoma the biopsies revealed a positive CEA reaction. In 4 patients with carcinoma diagnosed 1--2 years after the first examination the initial nonmalignant biopsies were CEA-positive in one case. All biopsies from mucosa with severe dysplasia and adenomatous polyps were CEA-positive. Four patients without malignant or premalignant changes in the gastric mucosa had CEA-positive biopsies. No carcinoma has been found in these patients at re-examinations after 1 year. The results indicate that the occurrence of immunohistochemically detectable CEA may be associated with malignant transformation of the gastric mucosa. The value of this method in screening patients at increased risk of gastric carcinoma will be further explored.
采用三层桥联免疫过氧化物酶技术，对49例患者在胃部分切除术后13至20年所取的胃活检标本中的癌胚抗原（CEA）进行了研究。常规组织学检查显示，所有患者均有不同程度的慢性萎缩性胃炎。在9例有恶性或癌前黏膜改变的患者中，有6例CEA反应呈阳性；在40例无这些改变的患者中，有4例呈阳性。在2例癌患者中，活检显示CEA反应呈阳性。在首次检查后1至2年诊断为癌的4例患者中，1例最初的非恶性活检标本CEA呈阳性。所有来自重度发育异常黏膜和腺瘤性息肉的活检标本CEA均呈阳性。4例胃黏膜无恶性或癌前改变的患者，其活检标本CEA呈阳性。在1年后的复查中，这些患者均未发现癌症。结果表明，免疫组化可检测到的CEA的出现可能与胃黏膜的恶性转化有关。该方法在筛查胃癌高危患者中的价值将进一步探讨。
