College of Acupuncture-moxibustion and Tuina, Guangxi University of Chinese Medicine, Nanning 530001, China.
Zhen Ci Yan Jiu. 2024 Apr 25;49(4):424-433. doi: 10.13702/j.1000-0607.20221333.
OBJECTIVES: To explore the rules of acupoint selection in the treatment of metabolic-associated fatty liver disease (MAFLD) with acupuncture and moxibustion by using data mining technology. METHODS: The clinical research literature on acupuncture treatment of MAFLD was collected from PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Database, VIP Database and China Biology Medicine from their inception to November 20, 2022. According to our inclusion and exclusion criteria, the literature was independently screened and re-screened by two research members, and the screened results were checked, followed by establishing an acupoint prescription database using Excel 2019. Descriptive statistics of acupoints applied frequency, involved meridians, locations and specific acupoints were perpormed. Then, SPSS Modeler18.0 software was used to conduct analysis about association rules, and the SPSS Statistics 26.0 software was used to perform cluster analysis on high-frequency acupoints, exploring the characteristics and rules of acupoint selection and combination in the treatment of MAFLD. RESULTS: Totally, 178 papers were collected, containing 130 acupoints, with a total application frequency of 1 305. The top five acupoints are Zusanli (ST36), Fenglong (ST40), Ganshu (BL18), Taichong (LR3) and Sanyinjiao (SP6). The commonly involved meridians are the Stomach Meridian of Foot Yangming, Bladder Meridian of Foot Taiyang, and Spleen Meridian of Foot Taiyin. The employed acupoints are mostly located in the lower limbs and abdomen, and the five acupoints and crossing acupoints are in the majority. The association rule analysis of high frequency acupoints indicated that of the 16 qualified acupoint groups, the top 5 with close correlation degrees are ST36 and ST40, ST36 and LR3, ST36 and SP6, ST40 and LR3 and ST36, ST36 and SP6 and ST40. Further, 3 effective clusters were obtained by cluster analysis. CONCLUSIONS: Acupuncture and moxibustion treatment of MAFLD follows the therapeutic principles of soothing the liver, invigorating the spleen, tonifying the kidney, and resolving phlegm and removing dampness. The core acupoint group is ST36, ST40 and LR3, and the combination of acupoints is based on syndrome differentiation. These results may provide a useful reference for clinical practice.
目的：运用数据挖掘技术探讨针灸治疗代谢相关脂肪性肝病（MAFLD）的选穴规律。
方法：检索 PubMed、Embase、Cochrane 图书馆、中国知网、万方数据库、维普数据库和中国生物医学文献数据库自建库至 2022 年 11 月 20 日收录的针灸治疗 MAFLD 的临床研究文献，按照纳入和排除标准由 2 位研究人员独立筛选和再筛选文献，并对筛选结果进行核对，然后采用 Excel 2019 建立穴位处方数据库。对穴位应用频次、涉及经络、部位和特定穴位进行描述性统计分析。采用 SPSS Modeler18.0 软件进行关联规则分析，SPSS Statistics 26.0 软件对高频穴位进行聚类分析，探讨针灸治疗 MAFLD 的选穴特点和规律。
结果：共纳入 178 篇文献，包含 130 个穴位，总应用频次为 1 305 次。前 5 位穴位依次为足三里（ST36）、丰隆（ST40）、肝俞（BL18）、太冲（LR3）和三阴交（SP6）。常用经络为足阳明胃经、足太阳膀胱经和足太阴脾经。选用穴位多位于下肢和腹部，且以五输穴和交会穴为主。高频穴位的关联规则分析表明，16 个合格的穴位组合中，关联度较高的前 5 组依次为 ST36 和 ST40、ST36 和 LR3、ST36 和 SP6、ST40 和 LR3、ST36 和 SP6 和 ST40。进一步通过聚类分析得到 3 个有效聚类。
结论：针灸治疗 MAFLD 遵循疏肝健脾、补肾化痰祛湿的治疗原则。核心穴位组为 ST36、ST40 和 LR3，穴位组合以辨证论治为基础。这些结果可能为临床实践提供有益参考。
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