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基于数据挖掘的穴位在针刺治疗偏头痛中的应用规律及临床意义探索

Exploration of the Application Rules and Clinical Significance of Acupoints in Acupuncture Treatment of Migraine Based on Data Mining.

作者信息

He Yujun, Wang Xiaoyi, Liu Minhui, Li Lu, Han Tingfen, Wu Yachao, Li Xiaojun

机构信息

Department of Traditional Chinese Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, People's Republic of China.

出版信息

J Pain Res. 2025 Jun 18;18:3049-3067. doi: 10.2147/JPR.S527987. eCollection 2025.

DOI:10.2147/JPR.S527987
PMID:40546831
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12182733/
Abstract

BACKGROUND: Abundant clinical investigations have attested to the efficacy of acupuncture in treating migraines. However, as each acupoint elicits distinct analgesic pathways and acupuncturists vary in their acupoint selection, there is currently an absence of evidence-based guidance for determining the optimal acupoint selection. OBJECTIVE: The aim of this study was to conduct an initial comprehensive data mining analysis to identify the most effective acupoints and their combinations for migraine treatment. METHODS: A comprehensive search was carried out in eight electronic bibliographic databases (PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Database, Chinese Biomedical Literature Database, and Chongqing VIP Database) from their inception up to May 2025. Studies evaluating the effectiveness of acupuncture in treating migraines were selected. The literature was rigorously evaluated according to predefined inclusion and exclusion criteria, and relevant data were then extracted for analysis. Excel 2021 was used for descriptive statistical analysis. Association rule analysis was performed using SPSS Modeler 14.1. Exploratory factor analysis, cluster analysis, and decision tree analysis were conducted using SPSS Statistics 26.0. RESULTS: A total of 911 trials were identified, from which 1610 groups of effective prescriptions involving 181 acupoints were extracted. The most commonly used acupoints were Feng-chi (GB20), Tai-yang (EX-HN5), Shuai-gu (GB8), Bai-hui (GV20), and He-gu (LI4). The gallbladder meridian was the most frequently utilized meridian. Specific points, mainly crossing points, were predominantly used, with head and neck acupoints being the most common. The combination of "Feng-chi (GB20), Tai-yang (EX-HN5), and Shuai-gu (GB8)" was frequently used as the core acupoints group. Additionally, several acupoint combinations were obtained through exploratory factor analysis, cluster analysis, and decision tree analysis. CONCLUSION: This research provides evidence-based support for the effectiveness of acupoint selection in migraine treatment and offers potential therapeutic recommendations, thereby facilitating collaborative decision-making between healthcare providers and patients.

摘要

背景：大量临床研究证实了针灸治疗偏头痛的疗效。然而，由于每个穴位引发不同的镇痛途径，且针灸师的穴位选择各不相同，目前缺乏基于证据的指导来确定最佳穴位选择。 目的：本研究旨在进行初步的全面数据挖掘分析，以确定治疗偏头痛最有效的穴位及其组合。 方法：从八个电子文献数据库（PubMed、Embase、Cochrane图书馆、Web of Science、中国知网、万方数据库、中国生物医学文献数据库和重庆维普数据库）自创建至2025年5月进行全面检索。选择评估针灸治疗偏头痛有效性的研究。根据预先定义的纳入和排除标准对文献进行严格评估，然后提取相关数据进行分析。使用Excel 2021进行描述性统计分析。使用SPSS Modeler 14.1进行关联规则分析。使用SPSS Statistics 26.0进行探索性因子分析、聚类分析和决策树分析。 结果：共识别出911项试验，从中提取了涉及181个穴位的1610组有效处方。最常用的穴位为风池（GB20）、太阳（EX-HN5）、率谷（GB8）、百会（GV20）和合谷（LI4）。足少阳胆经是最常使用的经络。主要使用特定穴位，主要是交会穴，头颈部穴位最为常见。“风池（GB20）、太阳（EX-HN5）、率谷（GB8）”组合常被用作核心穴位组。此外，通过探索性因子分析、聚类分析和决策树分析获得了几组穴位组合。 结论：本研究为偏头痛治疗中穴位选择的有效性提供了循证支持，并提供了潜在的治疗建议，从而促进医疗服务提供者与患者之间的共同决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/c340de97956d/JPR-18-3049-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/f7b1220e0147/JPR-18-3049-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/503a8f9d8838/JPR-18-3049-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/ae440a9a32be/JPR-18-3049-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/aaf424861069/JPR-18-3049-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/25aacfe08b1a/JPR-18-3049-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/c1e7fcd1a294/JPR-18-3049-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/c340de97956d/JPR-18-3049-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/f7b1220e0147/JPR-18-3049-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/503a8f9d8838/JPR-18-3049-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/ae440a9a32be/JPR-18-3049-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/aaf424861069/JPR-18-3049-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/25aacfe08b1a/JPR-18-3049-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/c1e7fcd1a294/JPR-18-3049-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cea8/12182733/c340de97956d/JPR-18-3049-g0007.jpg

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引用本文的文献

[1]
Exploration of the Application Rules and Clinical Significance of Acupoints in Acupuncture Treatment of Migraine Based on Data Mining [Letter].

J Pain Res. 2025-7-3

本文引用的文献

[1]
Analysis of Acupoint Selection and Combinations in Acupuncture Treatment of Migraine: A Protocol for Data Mining.

J Pain Res. 2024-12-10

[2]
Restoring brain health: Electroacupuncture at GB20 and LR3 for migraine mitigation through mitochondrial restoration.

Brain Circ. 2024-6-26

[3]
Auricular Therapy for Migraine.

Curr Pain Headache Rep. 2024-8

[4]
Analysis on acupoint selection rules in the treatment of metabolism-associated fatty liver disease based on data mining.

Zhen Ci Yan Jiu. 2024-4-25

[5]
A Data Mining Study for Analysis of Acupoint Selection and Combinations in Acupuncture Treatment of Carpal Tunnel Syndrome.

J Pain Res. 2024-3-18

[6]
Acupoint selection rules of acupuncture and moxibustion in treating neurogenic bladder based on data mining.

Zhen Ci Yan Jiu. 2024-2-25

[7]
Potential treatment targets for migraine: emerging options and future prospects.

Lancet Neurol. 2024-3

[8]
Analysis of Acupoint Selection and Combinations in Acupuncture Treatment of Piriformis Syndrome: A Protocol for Data Mining.

J Pain Res. 2023-9-28

[9]
Analysis of Acupoint Selection and Combinations in Acupuncture Treatment of Carpal Tunnel Syndrome: A Protocol for Data Mining.

J Pain Res. 2023-6-7

[10]
Electroacupuncture at Fengchi(GB20) and Yanglingquan(GB34) Ameliorates Paralgesia through Microglia-Mediated Neuroinflammation in a Rat Model of Migraine.

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