共济失调毛细血管扩张症细胞经辐照和未经辐照时DNA合成的改变
Altered DNA synthesis in irradiated and unirradiated ataxia-telangiectasia cells.
作者信息
Painter R B
出版信息
Kroc Found Ser. 1985;19:89-100.
DNA synthesis in cells from ataxia-telangiectasia (AT) patients differs from that in normal cells in two principal ways. In unirradiated cultures, AT cells have a lower inherent rate of DNA synthesis (and, therefore, a longer S phase) than normal cells and, in cultures exposed to ionizing radiation, DNA synthesis is not inhibited as it is in normal cells; this radioresistant DNA synthesis is due to completely resistant DNA chain elongation and partially resistant DNA replicon initiation. It is probable that the defects in DNA synthesis in irradiated and unirradiated cells are related and are at least partially involved in the pathogenesis of this syndrome.
共济失调毛细血管扩张症（AT）患者细胞中的DNA合成与正常细胞中的DNA合成在两个主要方面存在差异。在未受辐射的培养物中，AT细胞的DNA合成固有速率低于正常细胞（因此，S期更长），并且在暴露于电离辐射的培养物中，DNA合成不像在正常细胞中那样受到抑制；这种抗辐射的DNA合成是由于DNA链延伸完全抗性和DNA复制子起始部分抗性。照射和未照射细胞中DNA合成的缺陷可能是相关的，并且至少部分参与了该综合征的发病机制。
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