Department of Neurology, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, China.
School of Instrument Science and Opto-Electronics Engineering of Beijing Information Science and Technology University, Beijing, China.
Apoptosis. 2024 Aug;29(7-8):1007-1018. doi: 10.1007/s10495-024-01969-y. Epub 2024 Apr 22.
Ischemic vascular diseases are on the rise globally, including ischemic heart diseases, ischemic cerebrovascular diseases, and ischemic peripheral arterial diseases, posing a significant threat to life. Copper is an essential element in various biological processes, copper deficiency can reduce blood vessel elasticity and increase platelet aggregation, thereby increasing the risk of ischemic vascular disease; however, excess copper ions can lead to cytotoxicity, trigger cell death, and ultimately result in vascular injury through several signaling pathways. Herein, we review the role of cuproptosis and copper deficiency implicated in ischemic injury and repair including myocardial, cerebral, and limb ischemia. We conclude with a perspective on the therapeutic opportunities and future challenges of copper biology in understanding the pathogenesis of ischemic vascular disease states.
缺血性血管疾病在全球呈上升趋势，包括缺血性心脏病、缺血性脑血管疾病和缺血性外周动脉疾病，对生命构成重大威胁。铜是各种生物过程中的必需元素，铜缺乏会降低血管弹性并增加血小板聚集，从而增加缺血性血管疾病的风险；然而，过量的铜离子会导致细胞毒性，引发细胞死亡，并通过几种信号通路最终导致血管损伤。在此，我们综述了铜死亡和铜缺乏在心肌、脑和肢体缺血等缺血损伤和修复中的作用。最后，我们从铜生物学在理解缺血性血管疾病发病机制方面的治疗机会和未来挑战的角度进行了讨论。
