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孕期使用覆盆子叶(悬钩子属):一项前瞻性观察研究。

Raspberry leaf (Rubus idaeus) use in pregnancy: a prospective observational study.

作者信息

Bowman Rebekah L, Taylor Jan, Davis Deborah L

机构信息

University of Canberra, Canberra, Australia.

University of Canberra and ACT Government, Health Directorate, Canberra, Australia.

出版信息

BMC Complement Med Ther. 2024 Apr 22;24(1):169. doi: 10.1186/s12906-024-04465-7.

Abstract

BACKGROUND

Raspberry leaf use during pregnancy in Australia is widespread. There has been little research exploring the potential beneficial or harmful effects of raspberry leaf on pregnancy, labour, and birth. More research is needed to appropriately inform childbearing women and maternity healthcare professionals on the effects of raspberry leaf so that women can make informed choices.

METHODS

This study aimed to determine associations between raspberry leaf use in pregnancy and augmentation of labour and other secondary outcomes. Data was derived from questionnaires which captured demographic information and herbal use in pregnancy. Clinical outcomes were accessed from the maternity services' clinical database. Data analysis was conducted in R via package 'brms' an implementation for Bayesian regression models.

RESULTS

A total of 91 completed records were obtained, 44 exposed to raspberry leaf and 47, not exposed. A smaller proportion of women in the raspberry leaf cohort had augmentation of labour, epidural anaesthesia, instrumental births, caesarean section, and postpartum haemorrhage. A larger proportion had vaginal birth and length of all phases of labour were shorter. Under these conditions the use of raspberry leaf was strongly predictive of women not having their labours medically augmented.

CONCLUSIONS

While our study demonstrated that raspberry leaf was strongly predictive of women not having their labours medically augmented, the results cannot be relied on or generalised to the wider population of pregnant women. While there were no safety concerns observed in our study, this should not be taken as evidence that raspberry leaf is safe. A randomised controlled trial is urgently needed to provide women and healthcare providers with robust evidence on which to base practice.

摘要

背景

在澳大利亚,孕期食用覆盆子叶的情况很普遍。关于覆盆子叶对妊娠、分娩和出生的潜在有益或有害影响的研究很少。需要更多的研究来为育龄妇女和产科医护人员提供关于覆盆子叶影响的适当信息,以便妇女能够做出明智的选择。

方法

本研究旨在确定孕期食用覆盆子叶与引产及其他次要结局之间的关联。数据来自问卷调查,这些问卷收集了人口统计学信息和孕期草药使用情况。临床结局从产科服务的临床数据库中获取。数据分析在R中通过“brms”软件包进行,该软件包用于贝叶斯回归模型。

结果

共获得91份完整记录,44人接触过覆盆子叶,47人未接触过。接触覆盆子叶组中较少比例的妇女进行了引产、硬膜外麻醉、器械助产、剖宫产和产后出血。较大比例的妇女进行了阴道分娩,且各产程的长度较短。在这些情况下,食用覆盆子叶强烈预示着妇女不会接受医学引产。

结论

虽然我们的研究表明,覆盆子叶强烈预示着妇女不会接受医学引产,但这些结果不能依赖,也不能推广到更广泛的孕妇群体。虽然我们的研究中未观察到安全问题,但这不应被视为覆盆子叶安全的证据。迫切需要进行一项随机对照试验,为妇女和医疗服务提供者提供可靠的证据,以便他们据此开展实践。

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