Kloke O, Osieka R
Klin Wochenschr. 1985 Oct 15;63(20):1081-2. doi: 10.1007/BF01739677.
A synergistic effect of etoposide and cyclosporin A was observed in a patient with acute T-lymphocytic leukemia in relapse. The concomitant administration of etoposide and cyclosporin A resulted in eradication of hitherto refractory leukemic infiltration of bone marrow. Severe side effects in terms of mental confusion and progressive hyperbilirubinemia, however, point to an enhancement not only of antineoplastic effects but also of toxicity in normal tissues. This report demonstrates for the first time that the pharmacodynamic properties of cyclosporin A may not be confined strictly to suppression of normal T-cell functions.
在一名复发的急性T淋巴细胞白血病患者中观察到依托泊苷和环孢素A的协同作用。依托泊苷和环孢素A联合使用导致迄今难治的骨髓白血病浸润得以消除。然而，严重的副作用，如精神错乱和进行性高胆红素血症，表明不仅抗肿瘤作用增强，正常组织的毒性也增强。本报告首次证明环孢素A的药效学特性可能并不严格局限于抑制正常T细胞功能。
