Division of Pediatric Nephrology, Department of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.
Pediatr Transplant. 2024 May;28(3):e14762. doi: 10.1111/petr.14762.
Antibodies to angiotensin II type 1 receptor (AT1R-Abs) are among the most well-studied non-HLA antibodies in renal transplantation. These antibodies have been shown to be common in pediatric kidney transplantation and associated with antibody-mediated rejection (AMR), vascular inflammation, development of human leukocyte donor-specific antibodies (HLA DSA), and allograft loss. As AT1R-Ab testing becomes more readily accessible, evidence to guide clinical practice for testing and treating AT1R-Ab positivity in pediatric kidney transplant recipients remains limited. This review discusses the clinical complexities of evaluating AT1R-Abs given the current available evidence.
血管紧张素 II 型 1 型受体 (AT1R-Abs) 抗体是肾移植中研究最充分的非 HLA 抗体之一。这些抗体在儿科肾移植中很常见，与抗体介导的排斥反应 (AMR)、血管炎症、人类白细胞供体特异性抗体 (HLA DSA) 的发展和移植物丢失有关。随着 AT1R-Ab 检测变得更加容易获得，用于指导儿科肾移植受者检测和治疗 AT1R-Ab 阳性的临床实践的证据仍然有限。鉴于现有证据，本综述讨论了评估 AT1R-Abs 的临床复杂性。
