Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Department of Integrative Biology, School of Bioscience and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Environ Sci Process Impacts. 2024 Jul 17;26(7):1130-1146. doi: 10.1039/d4em00010b.
Despite a significant amount of research on micronanoplastics (MNPs), there is still a gap in our understanding of their function as transporters of other environmental pollutants (known as the Trojan horse effect) and the combined effects of ingestion, bioaccumulation, and toxicity to organisms. This study examined the individual effects of polystyrene nanoplastics (PSNPs) with various surface functionalizations (plain (PS), carboxylated (PS-COOH), and aminated (PS-NH)), particle sizes (100 nm and 500 nm), and a pharmaceutical co-contaminant (metformin hydrochloride (MH), an anti-diabetic drug) on the marine crustacean - . The study specifically aimed to determine if MH alters the detrimental effects of PSNPs on . The potential toxicity of these emerging pollutants was assessed by examining mortality, hatching rate, morphological changes, and biochemical changes. Smaller nanoparticles had a more significant impact than larger ones, and PS-NH was more harmful than PS and PS-COOH. Exposure to the nanoparticle complex with MH resulted in a decrease in hatching rate, an increase in mortality, developmental abnormalities, an increase in reactive oxygen species, catalase, and lipid peroxidase, and a decrease in total protein and superoxide dismutase, indicating a synergistic effect. There were no significant differences between the complex and the individual nanoparticles. However, accumulating these particles in organisms could contaminate the food chain. These results highlight the potential environmental risks associated with the simultaneous exposure of aquatic species to plastics, particularly smaller PS, aminated PS, and pharmaceutical complex PS.
尽管已经对微纳米塑料（MNPs）进行了大量研究，但我们对它们作为其他环境污染物载体的功能（即“特洛伊木马效应”）以及摄入、生物累积和对生物体毒性的综合影响的理解仍存在差距。本研究考察了具有不同表面功能化（普通（PS）、羧基化（PS-COOH）和氨基化（PS-NH））、粒径（100nm 和 500nm）和一种药物共污染物（盐酸二甲双胍（MH），一种抗糖尿病药物）的聚苯乙烯纳米塑料（PSNP）对海洋甲壳类动物-的单独影响。本研究旨在确定 MH 是否会改变 PSNP 对的有害影响。通过检查死亡率、孵化率、形态变化和生化变化来评估这些新兴污染物的潜在毒性。较小的纳米颗粒比较大的纳米颗粒产生更大的影响，而 PS-NH 比 PS 和 PS-COOH 更具危害性。暴露于含有 MH 的纳米颗粒复合物会导致孵化率降低、死亡率增加、发育异常、活性氧增加、过氧化氢酶和脂质过氧化物酶增加以及总蛋白和超氧化物歧化酶减少，表明存在协同效应。复合物和单个纳米颗粒之间没有显著差异。然而，这些颗粒在生物体中的积累可能会污染食物链。这些结果强调了同时使水生物种暴露于塑料，特别是较小的 PS、氨基化 PS 和药物复合 PS 可能带来的潜在环境风险。
