Pelissari Daniele Maria, Lima Lucas Vinícius de, Pavinati Gabriel, Magnabosco Gabriela Tavares, Silva Júnior José Nildo de Barros, Bartholomay Patricia, Johansen Fernanda Dockhorn Costa
Ministério da Saúde, Coordenação-Geral de Vigilância da Tuberculose, Endemic Mycoses and Non-Tuberculous Mycobacteria - Brasília (DF), Brazil.
Universidade Estadual de Maringá, Postgraduate Nursing Program - Maringá (PR), Brazil.
Rev Bras Epidemiol. 2024 Apr 19;27:e240016. doi: 10.1590/1980-549720240016. eCollection 2024.
To calculate the rate of tuberculosis recurrence, estimate its average time until recurrence, and identify factors associated with recurrence in Brazil.
Retrospective cohort study with a linked database from the Notifiable Diseases Information System. The study included individuals diagnosed with tuberculosis in 2015, focusing on those who experienced their first recurrence within 6.5 years. We estimated the relative risk (RR) and its 95% confidence interval (95%CI), as well as the population attributable fraction (PAF) or the population preventable fraction (PPF) of associated factors.
Within a 6.5-year period, 3,253 individuals (6.5%) experienced tuberculosis recurrence, with a median time of 2.2 years. Positively associated factors included: male sex (RR: 1.4; 95%CI 1.3-1.5; PAF: 22.9%), age 30 to 59 years (RR: 3.0; 95%CI 1.6-5.7; PAF: 36.0%), black race (RR: 1.3; 95%CI 1.2-1.5; PAF: 3.5%), mixed race (RR: 1.3; 95%CI 1.2-1.4; PAF: 10.6%), deprivation of liberty (RR: 1.9; 95%CI 1.7-2.1; PAF: 9.1%), pulmonary/mixed clinical form (RR: 1.7; 95%CI 1.4-1.9; PAF: 37.1%), acquired immunodeficiency syndrome diagnosis (RR: 1.8; 95%CI 1.5-1.9; PAF: 4.3%), and alcohol use (RR: 1.2; 95%CI 1.1-1.3; PAF: 2.9%). Negatively associated factors were: 12 or more years of schooling (RR: 0.5; 95%CI 0.4-0.6; PPF: 3.3%) and supervised treatment (RR: 0.9; 95%CI 0.8-0.9; PPF: 4.4%).
This study revealed high tuberculosis recurrence rates in Brazil, influenced by sociodemographic, compartmental, and social factors, both positively and negatively impacting disease recurrence.
计算巴西结核病复发率，估计其复发前的平均时间，并确定与复发相关的因素。
采用回顾性队列研究，使用来自法定传染病信息系统的关联数据库。该研究纳入了2015年被诊断为结核病的个体，重点关注在6.5年内首次复发的患者。我们估计了相对风险（RR）及其95%置信区间（95%CI），以及相关因素的人群归因分数（PAF）或人群可预防分数（PPF）。
在6.5年的时间里，3253名个体（6.5%）出现了结核病复发，中位时间为2.2年。正相关因素包括：男性（RR：1.4；95%CI 1.3 - 1.5；PAF：22.9%）、30至59岁（RR：3.0；95%CI 1.6 - 5.7；PAF：36.0%）、黑人种族（RR：1.3；95%CI 1.2 - 1.5；PAF：3.5%）、混血种族（RR：1.3；95%CI 1.2 - 1.4；PAF：10.6%）、被剥夺自由（RR：1.9；95%CI 1.7 - 2.1；PAF：9.1%）、肺/混合型临床类型（RR：1.7；95%CI 1.4 - 1.9；PAF：37.1%）、获得性免疫缺陷综合征诊断（RR：1.
