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进行性肺纤维化和间质性肺异常:专家小组叙述性综述

Progressive Pulmonary Fibrosis and Interstitial Lung Abnormalities: Expert Panel Narrative Review.

作者信息

Kanne Jeffrey P, Walker Christopher M, Brixey Anupama G, Brown Kevin K, Chelala Lydia, Kazerooni Ella A, Walsh Simon L F, Lynch David A

机构信息

Department of Radiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Ave, Madison, WI 53792-3252.

Department of Radiology, The University of Kansas Medical Center, Kansas City, KS.

出版信息

AJR Am J Roentgenol. 2025 Mar;224(3):e2431125. doi: 10.2214/AJR.24.31125. Epub 2024 Apr 24.

Abstract

Progressive pulmonary fibrosis (PPF) and interstitial lung abnormalities (ILA) are relatively new concepts in interstitial lung disease (ILD) imaging and clinical management. Recognition of signs of PPF and identification and classification of ILA are important tasks during chest high-resolution CT interpretation to optimize management of patients with ILD and those at risk of developing ILD. However, in professional society guidance, the role of imaging surveillance remains unclear for stable patients with ILD, asymptomatic patients with ILA who are at risk of progression, and asymptomatic patients at risk of developing ILD without imaging abnormalities. In this Expert Panel Narrative Review, we summarize the current knowledge regarding PPF and ILA and describe the range of clinical practice with respect to imaging patients with ILD, those with ILA, and those at risk of developing ILD. In addition, we offer suggestions to help guide surveillance imaging in areas with an absence of published guidelines, where such decisions are currently driven primarily by local pulmonologists' preference.

摘要

进行性肺纤维化(PPF)和间质性肺异常(ILA)是间质性肺病(ILD)影像学和临床管理中相对较新的概念。在胸部高分辨率CT解读过程中,识别PPF的征象以及ILA的识别和分类是重要任务,以优化ILD患者及有发展为ILD风险患者的管理。然而,在专业学会的指南中,对于病情稳定的ILD患者、有进展风险的无症状ILA患者以及无影像学异常但有发展为ILD风险的无症状患者,影像学监测的作用仍不明确。在本专家小组叙述性综述中,我们总结了关于PPF和ILA的现有知识,并描述了针对ILD患者、ILA患者以及有发展为ILD风险患者进行影像学检查的临床实践范围。此外,在缺乏已发表指南的领域,我们提供建议以帮助指导监测影像学,目前这些领域的此类决策主要由当地肺科医生的偏好驱动。

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