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由于天花流行选择导致冰岛人类ABO血型频率可能发生的变化。

Possible changes in the frequency of the human ABO blood groups in Iceland due to smallpox epidemics selection.

作者信息

Adalsteinsson S

出版信息

Ann Hum Genet. 1985 Oct;49(4):275-81. doi: 10.1111/j.1469-1809.1985.tb01703.x.

DOI:10.1111/j.1469-1809.1985.tb01703.x
PMID:3865623
Abstract

The hypothesis is put forward that the low frequency of A and high frequency of O blood group genes in the Icelandic human population is the result of a selective disadvantage of A during severe smallpox epidemics. The hypothesis is supported by data from India in 1965-6, which show a marked selective effect of a smallpox epidemic against the phenotypes A and AB (Vogel & Chakravartti, 1971). The conclusion is drawn that the present-day ABO blood group gene frequencies of the Icelandic population should be used with reservation as markers in the study of the origin of the Icelanders.

摘要

有人提出这样的假说

冰岛人群中A血型基因频率低而O血型基因频率高是在严重天花流行期间A血型具有选择性劣势的结果。1965 - 1966年印度的数据支持了这一假说，这些数据显示天花流行对A和AB血型表型有显著的选择作用（沃格尔和恰克拉瓦蒂，1971）。由此得出结论，在研究冰岛人的起源时，冰岛人群目前的ABO血型基因频率作为标记应谨慎使用。

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