College of Life Sciences and Health, Wuhan University of Science and Technology, Wuhan 430065, China.
Food Funct. 2024 May 7;15(9):5073-5087. doi: 10.1039/d4fo00369a.
L-Arabinose, lactulose, and () have been reported to have glucolipid-lowering effects. Here, the effects of L-arabinose and lactulose combined with on obesity traits were investigated. According to the experimental results, the combination of L-arabinose, lactulose, and was more effective at reducing body weight, regulating glucolipid metabolism, and improving insulin resistance. Besides, this combination showed immunomodulatory activity by adjusting the T lymphocyte subsets and reduced the immune-related cytokine production. Moreover, it improved the gut barrier, ameliorated the disorder of gut microbiota, and upregulated the levels of SCFAs. More importantly, the AL group, LP group, and ALLP group showed different regulatory effects on the abundance of and due to the presence of lactulose and . These findings elucidate that the combination of L-arabinose, lactulose, and constitutes a new synbiotic combination to control obesity by modulating glucolipid metabolism, immunomodulatory activity, inflammation, gut barrier, gut microbiota and production of SCFAs.
L-阿拉伯糖、乳果糖和（）已被报道具有调节糖脂代谢的作用。在这里，研究了 L-阿拉伯糖和乳果糖与（）联合使用对肥胖特征的影响。根据实验结果，L-阿拉伯糖、乳果糖和（）的组合在降低体重、调节糖脂代谢和改善胰岛素抵抗方面更有效。此外，这种组合通过调节 T 淋巴细胞亚群表现出免疫调节活性，并减少免疫相关细胞因子的产生。此外，它改善了肠道屏障，改善了肠道微生物群的紊乱，并上调了 SCFAs 的水平。更重要的是，由于乳果糖和（）的存在，AL 组、LP 组和 ALLP 组对和（）的丰度表现出不同的调节作用。这些发现阐明了 L-阿拉伯糖、乳果糖和（）的组合通过调节糖脂代谢、免疫调节活性、炎症、肠道屏障、肠道微生物群和 SCFAs 的产生来控制肥胖的新共生组合。
