Lee K, Kubota T, Yoshimine F, Sawamura M, Tsuchimoto K, Toyoda H, Miyagawa T, Kobayashi E, Kadowaki K, Kawamura E
Gan To Kagaku Ryoho. 1985 Dec;12(12):2391-4.
Intravenous bolus injection of an 80- to 120-mg/m2 dose of cisplatin followed by "rescue" with sodium thiosulfate (STS) was tried in the treatment of 7 patients with advanced tumor. STS was given continuously i.v. six hours after cisplatin injection, combined with methylprednisolone and metoclopramide as antiemetics. Four patients were evaluable, consisting of one CR, one PR and two NC. Severe nausea and emesis occurred in two patients and irreversible renal dysfunction occurred in one. The clinical use of the STS rescue regimen was discussed in conjunction with our basic investigation of "STS-rescue" in an animal model.
对7例晚期肿瘤患者尝试采用静脉推注80至120毫克/平方米剂量的顺铂，随后用硫代硫酸钠（STS）“解救”的治疗方法。在顺铂注射6小时后持续静脉给予STS，并联合使用甲泼尼龙和甲氧氯普胺作为止吐药。4例患者可评估疗效，其中1例完全缓解（CR），1例部分缓解（PR），2例病情稳定（NC）。2例患者出现严重恶心和呕吐，1例出现不可逆的肾功能障碍。结合我们在动物模型中对“STS解救”的基础研究，讨论了STS解救方案的临床应用。
