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别怕出血:在肥胖症患者中实施标准化预防性肝素方案后评估术后出血发生率。

Don't Fear the Bleed: Assessing Postoperative Bleeding Incidence After Instituting a Standardized Prophylactic Heparin Protocol in Bariatric Patients.

作者信息

Chin Ryan, Berk Robin, Tagerman Daniel, Pereira Xavier, Friedmann Patricia, Camacho Diego

机构信息

Montefiore Medical Center, Bronx, New York, USA.

New York University Medical Center, New York, New York, USA.

出版信息

J Laparoendosc Adv Surg Tech A. 2024 May;34(5):401-406. doi: 10.1089/lap.2023.0532. Epub 2024 Apr 24.

Abstract

Bariatric surgery is a frequently performed procedure in the United States, accounting for ∼40,000 procedures annually. Patients undergoing bariatric surgery are at high risk for postoperative thrombosis, with a venous thromboembolism (VTE) rate of up to 6.4%. Despite this risk, there is a lack of guidelines recommending postoperative VTE prophylaxis and it is not routine practice at most hospitals. The postoperative bleeding rate after bariatric surgery is only 1.5%; however, the risk of bleeding may lead to hesitancy for more liberal VTE prophylaxis. This is a retrospective analysis of bariatric surgeries at a single institution in 2019 and 2021. Data were obtained from the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) and electronic medical record review for all patients undergoing sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), or conversion to RYGB. The primary outcomes were composite bleeding events, which included postoperative transfusion, postoperative endoscopy or return to operating room (OR) (for bleeding), intra-abdominal hematoma, gastrointestinal (GI) bleeding, or incisional hematoma. There were a total of 2067 patients in the cohort, with 1043 surgeries in 2019 and 1024 surgeries in 2021. There was no difference between bleeding events after instituting a deep venous thrombosis (DVT) prophylaxis protocol in 2021 (27 versus 28 events,  = .76). There was no difference in individual bleeding events between 2019 and 2021. Additionally, there was no significant difference in the rate of VTE between 2019 and 2021 (2 versus 5 events,  = .28). After instituting a standard protocol of prophylactic heparin postdischarge, we did not find an increased rate of bleeding events in patients undergoing bariatric surgery. Thus, surgeons can consider prescribing postdischarge chemical VTE prophylaxis without concern for bleeding.

摘要

减重手术在美国是一种常见的手术,每年约有40000例。接受减重手术的患者术后发生血栓形成的风险很高,静脉血栓栓塞(VTE)发生率高达6.4%。尽管存在这种风险,但缺乏推荐术后VTE预防措施的指南,而且在大多数医院这也不是常规做法。减重手术后的术后出血率仅为1.5%;然而,出血风险可能导致在更广泛地进行VTE预防时犹豫不决。这是对2019年和2021年在单一机构进行的减重手术的回顾性分析。数据来自代谢与减重手术认证和质量改进项目(MBSAQIP)以及对所有接受袖状胃切除术(SG)、Roux-en-Y胃旁路术(RYGB)或转为RYGB手术患者的电子病历审查。主要结局是复合出血事件,包括术后输血、术后内镜检查或返回手术室(因出血)、腹腔内血肿、胃肠道(GI)出血或切口血肿。该队列共有2067例患者,2019年有1043例手术,2021年有1024例手术。2021年实施深静脉血栓形成(DVT)预防方案后的出血事件与之前无差异(27例对28例事件,P = 0.76)。2019年和2021年之间的个体出血事件无差异。此外,2019年和2021年之间的VTE发生率也无显著差异(2例对5例事件,P = 0.28)。在实施出院后预防性使用肝素的标准方案后,我们未发现减重手术患者的出血事件发生率增加。因此,外科医生可以考虑在出院后开具化学性VTE预防药物,而无需担心出血问题。

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