Strasbourg Lung Transplant Program, Hôpitaux universitaires de Strasbourg, Strasbourg, France.
Laboratory of Virology, Hôpitaux universitaires de Strasbourg, Strasbourg, France.
Respir Med Res. 2024 Jun;85:101100. doi: 10.1016/j.resmer.2024.101100. Epub 2024 Mar 14.
Due to the COVID-19 pandemic, France underwent several lockdown periods during 2020. Our aim was to evaluate its clinical and social impact on lung transplant (LT) patients treated at Strasbourg University Hospital, by comparing three periods: first lockdown (T1: March-May 2020), end of the first lockdown (T2: May-October 2020), and second lockdown (T3: November-December 2020) and the incidence of COVID-19 infections. A cohort of patients with rare lung disease (RLD) was also studied during T2.
We used clinical and paraclinical data collected during routine follow-up. A questionnaire was submitted to each patient at each period to assess their lifestyle, adherence to protective measures against COVID-19, contacts with their family and friends, and contagion risk. The incidence of new COVID-19 cases was also assessed.
Overall, 283 LT and 57 RLD patients were included. We observed only eight COVID-19 cases over the three periods (n = 4 during T1, n = 0 during T2, and n = 4 during T3) in LT patients, with 37.5 % of patients hospitalized, no ICU transfers, and 100 % favorable outcomes. No case of COVID-19 was diagnosed in the RLD cohort. When comparing the three periods in the LT group, fewer patients limited their out-of-home activities during T2 (p < 0.0001). The frequency of these activities increased after the first lockdown, for the purchase of basic necessities (p < 0.0001), and professional activity continued (p = 0.008). We observed a significant increase in unscheduled medical consultations and in the prescription of anti-infective treatments during the end of the lockdown (p = 0.0002 and p = 0.005, respectively). Adherence to lockdown and to protective measures was high in both groups of patients.
COVID-19 incidence remained low in both groups and there were significant lifestyle evolutions in LT patients and in those with RLD between first and second lockdown.
由于 COVID-19 大流行，法国在 2020 年经历了几次封锁期。我们的目的是通过比较三个时期（第一次封锁期（T1：2020 年 3 月至 5 月）、第一次封锁期末（T2：2020 年 5 月至 10 月）和第二次封锁期（T3：2020 年 11 月至 12 月））来评估 COVID-19 对在斯特拉斯堡大学医院接受治疗的肺移植（LT）患者的临床和社会影响，并评估 COVID-19 感染的发生率。在 T2 期间，还对一组患有罕见肺部疾病（RLD）的患者进行了研究。
我们使用了在常规随访中收集的临床和临床前数据。在每个时期，我们都向每位患者提交了一份问卷，以评估他们的生活方式、对 COVID-19 保护措施的遵守情况、与家人和朋友的接触情况以及感染风险。还评估了新的 COVID-19 病例的发生率。
总体而言，纳入了 283 名 LT 和 57 名 RLD 患者。在 LT 患者中，我们仅在三个时期观察到 8 例 COVID-19 病例（T1 期间为 4 例，T2 期间为 0 例，T3 期间为 4 例），其中 37.5%的患者住院，无 ICU 转移，100%的患者预后良好。RLD 队列中未诊断出 COVID-19 病例。在 LT 组中，与 T2 相比，在 T2 期间限制户外活动的患者较少（p <0.0001）。第一次封锁后，这些活动的频率增加，用于购买基本必需品（p <0.0001），且职业活动继续进行（p = 0.008）。我们观察到，在封锁期末，非计划的医疗咨询和抗感染治疗的处方显著增加（p = 0.0002 和 p = 0.005）。两组患者对封锁和保护措施的遵守率均较高。
两组 COVID-19 的发病率均较低，LT 患者和 RLD 患者在第一次和第二次封锁期间的生活方式有明显变化。
