Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Oral Oncol. 2024 Jun;153:106729. doi: 10.1016/j.oraloncology.2024.106729. Epub 2024 Apr 24.
Extranodal extension (ENE) of lymph node metastasis is one of the most reliable prognostic indicators for patients with locally advanced oral cancer. Although multiple reports have found a close relationship between immune infiltration of tumors and patient clinical outcomes, its association with ENE is unknown.
We identified 234 human papillomavirus-negative (HPV-) oral cavity squamous cell carcinoma (OSCC) patients in The Cancer Genome Atlas and investigated the immune infiltration profiles of primary tumors and their association with survival.
Hierarchical clustering analysis clearly classified the overall immune infiltration status in OSCC into high immune or low immune groups. The combination of ENE positivity and low immune infiltration was strongly associated with poor overall survival (OS) compared to the combination of ENE positivity and high immune infiltration [hazard ratio 2.04 (95 %CI, 1.08-3.83); p = 0.024]. The immune infiltration status was not associated with OS rates in patients with ENE-negative or node negative tumors.
Overall Immune infiltration at the primary site was significantly associated with clinical outcome of OSCC patients with ENE.
淋巴结转移的结外扩展（ENE）是局部晚期口腔癌患者最可靠的预后指标之一。尽管多项报告发现肿瘤免疫浸润与患者临床结局密切相关，但与 ENE 的关系尚不清楚。
我们在癌症基因组图谱中鉴定了 234 例人乳头瘤病毒阴性（HPV-）口腔鳞状细胞癌（OSCC）患者，并研究了原发肿瘤的免疫浸润谱及其与生存的关系。
层次聚类分析清楚地将 OSCC 的整体免疫浸润状态分为高免疫或低免疫组。与 ENE 阳性和高免疫浸润的组合相比，ENE 阳性和低免疫浸润的组合与较差的总生存期（OS）密切相关[风险比 2.04（95%CI，1.08-3.83）；p=0.024]。在 ENE 阴性或淋巴结阴性肿瘤患者中，免疫浸润状态与 OS 率无关。
原发部位的整体免疫浸润与 ENE 的 OSCC 患者的临床结局显著相关。
