Department of Radiology, Stanford University Medical Center, Stanford, California;
iNDX.AI, Cupertino, California; and.
J Nucl Med. 2024 Jul 1;65(7):1004-1006. doi: 10.2967/jnumed.123.266659.
Prostate-specific membrane antigen (PSMA) is frequently overexpressed in nonprostate malignancies. This preclinical study investigated the molecular basis of the application of PMSA-targeting radiopharmaceuticals in breast cancer subtypes. The somatic copy number status and the transcriptomic and protein expressions of (gene name of PSMA) were analyzed across breast cancer subtypes in 998 patients from The Cancer Genome Atlas dataset. was frequently amplified in basallike breast cancer (BLBC) (32%) compared with luminal and human epidermal growth factor receptor 2-positive subtypes (16% and 17%, respectively; < 0.01). expression was higher in BLBC ( < 0.001) and was negatively correlated with estrogen-receptor and progesterone-receptor expressions. Consistently, the PSMA protein level was higher in BLBC ( < 0.05). Interestingly, expression was associated with relapse-free and distant metastasis-free survival in patients with BLBC. The BLBC subtype exhibited frequent amplification and overexpression of PSMA, supporting the exploration of PSMA-targeting radiopharmaceuticals in this aggressive breast cancer subtype.
前列腺特异性膜抗原（PSMA）在非前列腺恶性肿瘤中常过度表达。本临床前研究调查了 PSMA 靶向放射性药物在乳腺癌亚型中应用的分子基础。在癌症基因组图谱（The Cancer Genome Atlas，TCGA）数据集中 998 例患者中，分析了 PSMA 靶向放射性药物在乳腺癌亚型中的体细胞拷贝数状态以及 （PSMA 的基因名称）的转录组和蛋白表达。PSMA 在基底样乳腺癌（BLBC）中经常扩增（32%），而在 luminal 和人表皮生长因子受体 2 阳性亚型中分别扩增（16%和 17%；<0.01）。BLBC 中 PSMA 的表达水平更高（<0.001），并且与雌激素受体和孕激素受体的表达呈负相关。同样，BLBC 中 PSMA 蛋白水平也更高（<0.05）。有趣的是，PSMA 的表达与 BLBC 患者的无复发生存和无远处转移生存相关。BLBC 亚型表现出 PSMA 的频繁扩增和过表达，支持在这种侵袭性乳腺癌亚型中探索 PSMA 靶向放射性药物。
