单侧肾切除术后肾血管舒张

Renal vasodilation after unilateral renal ablation.

作者信息

Hahne B, Karlberg L, Persson A E

出版信息

Ups J Med Sci. 1985;90(2):181-91. doi: 10.3109/03009738509178657.

Abstract

Renal blood flow was studied in rats 120 minutes after unilateral renal ablation. The influence of endogenous prostaglandin formation was evaluated by indomethacin treatment prior to the ablation. Radioactive microspheres were used for estimation of the total renal and cortical blood flow, and the renal medullary blood flow was determined with the 86-Rb chloride extraction method. The total blood flow in the remaining kidney was increased by 80% following contralateral ablation, with augmentation in all areas, particularly in the deep medullary region. Indomethacin treatment in intact rats evoked increased blood flow as compared with the indomethacin control group. The results indicated that the renal blood vessels respond to ablation of the contralateral kidney with dilation in all kidney regions, and that this vascular dilation may be prostaglandin-mediated.

摘要

在单侧肾切除术后120分钟对大鼠的肾血流量进行了研究。通过在肾切除术前用吲哚美辛治疗来评估内源性前列腺素形成的影响。放射性微球用于估计总肾血流量和皮质血流量，肾髓质血流量用氯化铷提取法测定。对侧肾切除后，剩余肾脏的总血流量增加了80%，所有区域均有增加，尤其是深部髓质区域。与吲哚美辛对照组相比，完整大鼠接受吲哚美辛治疗后血流量增加。结果表明，肾血管对侧肾切除的反应是所有肾区域均出现扩张，且这种血管扩张可能是由前列腺素介导的。