Patel Jaymin C, Cole Matthew, Rubis Amy B, Burzalff Kari, Cruz Victor, Edge Karen, Kudish Kathy, Liko Juventila, Pena Sandra, Thomas Ebony S, Skoff Tami H, McNamara Lucy A
Meningitis and Vaccine Preventable Diseases Branch, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Department of Health, New York State Department of Health, Albany, New York, USA.
Open Forum Infect Dis. 2024 Mar 26;11(4):ofae177. doi: 10.1093/ofid/ofae177. eCollection 2024 Apr.
An increased pertussis burden has been demonstrated among Hispanic or Latino and American Indian or Alaska Native (AI/AN) infants. However, data on potential disparities among other age and racial groups are limited.
We analyzed pertussis cases reported through Enhanced Pertussis Surveillance from 2010 to 2017. Pertussis and severe pertussis incidence were calculated by race (White, Black or African American, AI/AN, and Asian or Pacific Islanders), ethnicity (Hispanic or Latino and non-Hispanic or non-Latino), and age.
Compared with White persons, overall incidence was lower among Black or African American (incidence rate ratio [IRR], .57; 95% confidence interval [CI], .53-.61), AI/AN (IRR, 0.65; 95% CI, .58-.72), and Asian or Pacific Islander persons (IRR, 0.39; 95% CI, .35-.43). Overall incidence of pertussis was higher (1.5-fold; 95% CI, 1.37-1.60) among Hispanic or Latino compared with non-Hispanic or non-Latino adults, potentially related to household size or lower pertussis vaccine uptake among adult Hispanic or Latino cases. Severe pertussis incidence was similar among Black or African American and AI/AN persons compared with White persons. Among infants, severe pertussis incidence was 1.4-fold higher (95% CI, 1.03-1.82) among Black or African American infants than among White infants, and 2.1-fold higher (95% CI, 1.67-2.57) among Hispanic or Latino infants than non-Hispanic or non-Latino infants.
The contrast between lower reported incidence but similar or higher severe pertussis incidence among Black or African American and AI/AN persons compared with White persons warrants further investigation and may reflect underdiagnosis or underreporting of mild disease.
西班牙裔或拉丁裔以及美国印第安人或阿拉斯加原住民（AI/AN）婴儿中的百日咳负担已有所增加。然而，关于其他年龄和种族群体之间潜在差异的数据有限。
我们分析了2010年至2017年通过强化百日咳监测报告的百日咳病例。按种族（白人、黑人或非裔美国人、AI/AN、亚洲人或太平洋岛民）、族裔（西班牙裔或拉丁裔以及非西班牙裔或非拉丁裔）和年龄计算百日咳和重症百日咳发病率。
与白人相比，黑人或非裔美国人（发病率比[IRR]，0.57；95%置信区间[CI]，0.53 - 0.61）、AI/AN（IRR，0.65；95% CI，0.58 - 0.72）以及亚洲人或太平洋岛民（IRR，0.39；95% CI，0.35 - 0.43）的总体发病率较低。与非西班牙裔或非拉丁裔成年人相比，西班牙裔或拉丁裔成年人的百日咳总体发病率较高（1.5倍；95% CI，1.37 - 1.60），这可能与家庭规模或成年西班牙裔或拉丁裔病例中百日咳疫苗接种率较低有关。与白人相比，黑人或非裔美国人和AI/AN人群中的重症百日咳发病率相似。在婴儿中，黑人或非裔美国婴儿的重症百日咳发病率比白人婴儿高1.4倍（95% CI，1.03 - 1.82），西班牙裔或拉丁裔婴儿的重症百日咳发病率比非西班牙裔或非拉丁裔婴儿高2.1倍（95% CI，1.67 - 2.57）。
与白人相比，黑人或非裔美国人和AI/AN人群中报告的发病率较低，但重症百日咳发病率相似或较高，这一差异值得进一步调查，可能反映了轻度疾病的诊断不足或报告不足。
