用于改善宫颈条件不佳患者足月引产和促宫颈成熟的前列腺素E2凝胶

PGE2 gel for enhancement of priming and induction of labour at term in patients with unfavorable cervix.

作者信息

Silva-Cruz A, Pinto J M, Tavares J M, Valério O, Cardoso C

出版信息

Eur J Obstet Gynecol Reprod Biol. 1985 Dec;20(6):331-6. doi: 10.1016/0028-2243(85)90056-5.

Abstract

Fifty women (25 nulliparae and 25 multiparae) with unfavorable cervix at term were enrolled in a clinical experiment to evaluate the safety and efficacy of the intracervical application of 0.5 mg PGE2 gel for cervical softening and eventual induction of labour; duration of pregnancy (38-42 wk) was confirmed by ultrasonic records. Global analysis revealed 48 (96%) vaginal deliveries, 43 (86%) being spontaneous labour and 5 (10%) instrumentally assisted deliveries (forceps). Caesarean section was required in 2 cases (4%). Three patients, having registered no Bishop score (above 5) progress after the first treatment, went into labour upon the second application of PGE2 gel. Mean induction-delivery time was 11 h 50 min for nulliparae and 7 h 50 min for multiparae. Mean ROM/amniotomy-delivery time was 5 h 59 min for nulliparae and 3 h 11 min for multiparae. Four neonates with initial Apgar scores below 7 registered immediately higher values after adequate reanimation manouvres.

摘要

五十名足月宫颈条件不佳的女性（25名初产妇和25名经产妇）参与了一项临床试验，以评估宫颈内应用0.5毫克前列腺素E2凝胶软化宫颈并最终引产的安全性和有效性；妊娠时长（38 - 42周）通过超声记录得以确认。整体分析显示，48例（96%）为阴道分娩，其中43例（86%）为自然分娩，5例（10%）为器械辅助分娩（产钳）。2例（4%）需要剖宫产。3例患者在首次治疗后宫颈Bishop评分（高于5分）无进展，在第二次应用前列腺素E2凝胶后进入产程。初产妇的平均引产至分娩时间为11小时50分钟，经产妇为7小时50分钟。初产妇的平均破膜/人工破膜至分娩时间为5小时59分钟，经产妇为3小时11分钟。4例初始阿氏评分低于7分的新生儿在进行充分复苏操作后，评分立即升高。