在宫颈条件不佳的足月患者中，阴道内与宫颈内应用前列腺素E2粘性凝胶进行宫颈准备及引产的比较。

Intravaginal versus intracervical application of prostaglandin E2 in viscous gel for cervical priming and induction of labor at term in patients with an unfavorable cervical state.

作者信息

Ekman G, Forman A, Marsál K, Ulmsten U

出版信息

Am J Obstet Gynecol. 1983 Nov 15;147(6):657-61. doi: 10.1016/0002-9378(83)90445-3.

Abstract

Sixty term pregnant women with unripe cervix were randomly given either 0.5 mg of prostaglandin E2 (PGE2) in 2 ml of gel intracervically or 4 mg of PGE2 in 3 ml of gel intravaginally to prime the cervix and/or to induce labor. In patients with a highly unfavorable cervix (cervical score less than or equal to 3), the intracervical application was significantly more effective than the intravaginal. In patients with a more favorable cervical state (cervical score 4 or 5), the two routes of application were equipotent. Gastrointestinal side effects were registered after intravaginal but not after intracervical application. Myometrial activity was significantly more increased after intravaginal than after intracervical gel application. All children were born in good condition with an Apgar score greater than 7 within 5 minutes.

摘要

60名宫颈未成熟的足月孕妇被随机分为两组，一组宫颈内给予2ml凝胶中含0.5mg前列腺素E2（PGE2），另一组阴道内给予3ml凝胶中含4mg PGE2，以促宫颈成熟和/或引产。对于宫颈条件极差（宫颈评分小于或等于3分）的患者，宫颈内给药比阴道内给药显著更有效。对于宫颈条件较好（宫颈评分4或5分）的患者，两种给药途径效果相当。阴道内给药后出现胃肠道副作用，而宫颈内给药后未出现。阴道内凝胶给药后子宫肌层活动的增加明显大于宫颈内凝胶给药后。所有新生儿状况良好，5分钟内阿氏评分均大于7分。