Flamm W G
IARC Sci Publ. 1985(65):199-201.
Beryllium-containing compounds have been studied extensively and have been known to be carcinogenic in animals since 1946. Beryllium salts and alloys were among the first nonradioactive, inorganic substances shown to induce osteogenic sarcoma in experimental animals. Beryllium-containing compounds have been demonstrated to be powerful pulmonary carcinogens in rats. To date, these compounds do not appear to be mutagenic, leaving open the question of their mechanism of action.
含铍化合物已得到广泛研究,自1946年以来便已知其在动物中具有致癌性。铍盐和铍合金是最早被证明能在实验动物中诱发骨肉瘤的非放射性无机物质之一。含铍化合物已被证明是大鼠体内强大的肺致癌物。迄今为止,这些化合物似乎没有致突变性,其作用机制仍是个未解之谜。