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用于偶极子定位和观察的脑磁图图谱查看器。

Magnetoencephalography Atlas Viewer for Dipole Localization and Viewing.

作者信息

Fonseca N C D, Bowerman Jason, Askari Pegah, Proskovec Amy L, Feltrin Fabricio Stewan, Veltkamp Daniel, Early Heather, Wagner Ben C, Davenport Elizabeth M, Maldjian Joseph A

机构信息

MEG Center of Excellence, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Advanced Neuroscience Imaging Research (ANSIR) Laboratory, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

出版信息

J Imaging. 2024 Mar 28;10(4):80. doi: 10.3390/jimaging10040080.

Abstract

Magnetoencephalography (MEG) is a noninvasive neuroimaging technique widely recognized for epilepsy and tumor mapping. MEG clinical reporting requires a multidisciplinary team, including expert input regarding each dipole's anatomic localization. Here, we introduce a novel tool, the "Magnetoencephalography Atlas Viewer" (MAV), which streamlines this anatomical analysis. The MAV normalizes the patient's Magnetic Resonance Imaging (MRI) to the Montreal Neurological Institute (MNI) space, reverse-normalizes MNI atlases to the native MRI, identifies MEG dipole files, and matches dipoles' coordinates to their spatial location in atlas files. It offers a user-friendly and interactive graphical user interface (GUI) for displaying individual dipoles, groups, coordinates, anatomical labels, and a tri-planar MRI view of the patient with dipole overlays. It evaluated over 273 dipoles obtained in clinical epilepsy subjects. Consensus-based ground truth was established by three neuroradiologists, with a minimum agreement threshold of two. The concordance between the ground truth and MAV labeling ranged from 79% to 84%, depending on the normalization method. Higher concordance rates were observed in subjects with minimal or no structural abnormalities on the MRI, ranging from 80% to 90%. The MAV provides a straightforward MEG dipole anatomic localization method, allowing a nonspecialist to prepopulate a report, thereby facilitating and reducing the time of clinical reporting.

摘要

脑磁图(MEG)是一种非侵入性神经成像技术,在癫痫和肿瘤定位方面得到广泛认可。MEG临床报告需要一个多学科团队,包括关于每个偶极子解剖定位的专家意见。在此,我们介绍一种新型工具——“脑磁图图谱查看器”(MAV),它简化了这种解剖分析。MAV将患者的磁共振成像(MRI)归一化到蒙特利尔神经病学研究所(MNI)空间,将MNI图谱反归一化到原始MRI,识别MEG偶极子文件,并将偶极子的坐标与其在图谱文件中的空间位置相匹配。它提供了一个用户友好的交互式图形用户界面(GUI),用于显示单个偶极子、组、坐标、解剖标签以及带有偶极子叠加的患者三平面MRI视图。它对临床癫痫患者获得的273个以上偶极子进行了评估。由三位神经放射科医生基于共识建立了地面真值,最低一致阈值为两人。根据归一化方法,地面真值与MAV标记之间的一致性范围为79%至84%。在MRI上结构异常最小或无结构异常的患者中观察到更高的一致性率,范围为80%至90%。MAV提供了一种简单的MEG偶极子解剖定位方法,使非专业人员能够预先填写报告,从而便于并减少临床报告时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edbe/11051542/d691c576c7e5/jimaging-10-00080-g001.jpg

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