Méndez-Sánchez Nahum, Coronel-Castillo Carlos E, Ramírez-Mejía Mariana Michelle
Unit Liver Research, Medica Sur Clinic & Foundation, Mexico City 14050, Mexico.
Faculty of Medicine, National Autonomous University of Mexico, Mexico City 04510, Mexico.
Pathogens. 2024 Apr 19;13(4):339. doi: 10.3390/pathogens13040339.
Chronic hepatitis C virus infection is an important cause of liver cirrhosis, hepatocellular carcinoma and death. Furthermore, it is estimated that about 40-70% of patients develop non-hepatic alterations in the course of chronic infection. Such manifestations can be immune-related conditions, lymphoproliferative disorders and metabolic alterations with serious adverse events in the short and long term. The introduction of new Direct-Acting Antivirals has shown promising results, with current evidence indicating an improvement and remission of these conditions after a sustained virological response.
慢性丙型肝炎病毒感染是肝硬化、肝细胞癌和死亡的重要原因。此外，据估计，约40%-70%的患者在慢性感染过程中会出现非肝脏改变。这些表现可能是免疫相关疾病、淋巴增殖性疾病和代谢改变，在短期和长期都会产生严重不良事件。新型直接抗病毒药物的引入已显示出有前景的结果，目前证据表明在持续病毒学应答后这些情况会得到改善和缓解。
