Department of Neuroimmunology, University of Campinas, Vital Brasil Street 251, Campinas, SP, Brazil.
Neuroradiology. 2024 Jul;66(7):1199-1202. doi: 10.1007/s00234-024-03366-3. Epub 2024 Apr 26.
Some studies have suggested an inflammatory role of the choroid plexus (CP) in the pathophysiology of multiple sclerosis (MS), but mainly in adult patients. We aimed to evaluate clinical and MRI parameters in patients with pediatric-onset multiple sclerosis (POMS). We included 10 patients with POMS and 16 healthy controls (HC), evaluating clinical and neuroimaging variables (cerebral cortex, CP, deep gray matter structures, and demyelinating lesions). Most patients were girls (80%), with a mean age of 15.3 years. POMS individuals had a higher CP volume (p = 0.012) and lower thalamic volume (p = 0.038) compared to HC. This study shows an enlargement of the CP and lower thalamic volume in POMS patients compared to HC.
一些研究表明脉络丛（CP）在多发性硬化症（MS）的病理生理学中具有炎症作用，但主要在成年患者中。我们旨在评估儿科发病多发性硬化症（POMS）患者的临床和 MRI 参数。我们纳入了 10 名 POMS 患者和 16 名健康对照者（HC），评估了临床和神经影像学变量（大脑皮层、CP、深部灰质结构和脱髓鞘病变）。大多数患者为女孩（80%），平均年龄为 15.3 岁。与 HC 相比，POMS 患者的 CP 体积更大（p=0.012），丘脑体积更小（p=0.038）。这项研究显示，与 HC 相比，POMS 患者的 CP 增大，丘脑体积减小。
