Górski Konrad, Zgliczyński Stanisław, Stelmachowska-Banaś Maria, Czajka-Oraniec Izabella, Zgliczyński Wojciech, Ciebiera Michał, Zgliczyńska Magdalena
Second Department of Obstetrics and Gynecology, Centre of Postgraduate Medical Education, Warsaw, Poland.
Department of Internal Medicine and Endocrinology, Medical University of Warsaw, Warsaw, Poland.
Rev Endocr Metab Disord. 2024 Aug;25(4):773-781. doi: 10.1007/s11154-024-09883-z. Epub 2024 Apr 26.
The review discusses the relationship between acromegaly and uterine fibroids. It highlights variations in research methodologies and inconsistent findings, emphasizing the complex nature of fibroid development and the role of the somatotropic axis. Additionally, it addresses demographic factors and examines the potential impact of therapies on the risk and prevalence of uterine fibroids in individuals with acromegaly. We conducted an analysis of previously published literature that examined the repercussions of acromegaly on gynecological health in female cohorts, with specific attention directed towards elucidating the prevalence of uterine fibroids. We suggest that larger, more focused studies are needed to understand the specific impact of different treatments on the occurrence of gynecological issues in acromegaly patients. Additionally, our study emphasizes the importance of factors such as disease duration and treatment effectiveness. We hypothesize that a relationship between acromegaly and uterine fibroids may occur. However, it remains an area of ongoing research, with the need for larger, multi-center studies to draw more definitive conclusions.
这篇综述讨论了肢端肥大症与子宫肌瘤之间的关系。它强调了研究方法的差异和不一致的研究结果，强调了肌瘤发生的复杂性以及生长激素轴的作用。此外，它还讨论了人口统计学因素，并研究了治疗方法对肢端肥大症患者子宫肌瘤风险和患病率的潜在影响。我们对之前发表的文献进行了分析，这些文献研究了肢端肥大症对女性队列中妇科健康的影响，特别关注子宫肌瘤的患病率。我们建议需要开展更大规模、更具针对性的研究，以了解不同治疗方法对肢端肥大症患者妇科问题发生情况的具体影响。此外，我们的研究强调了疾病持续时间和治疗效果等因素的重要性。我们推测肢端肥大症与子宫肌瘤之间可能存在关联。然而，这仍然是一个正在进行研究的领域，需要开展更大规模的多中心研究才能得出更明确的结论。
