Miederer S E, Lindstaedt H, Kutz K, Mayershofer R
Acta Hepatogastroenterol (Stuttg). 1979 Aug;26(4):314-8.
Eleven male and five female gastric ulcer outpatients as well as twenty eight male and seven female duodenal ulcer outpatients received Proglumide (1200 mg/day) or magnesiumtrisilicate (1320 mg/day) in a prospective double blind study. The sizes of the ulcers were assessed by endoscopy before and after 4 weeks therapy. A complete healing of gastric ulcers was observed in 75% (n = 8) of the patients receiving Proglumide and 25% (n = 8) of the antacid treated controls (p less than 0.05; x2 test). The healed area was significantly (p less than 0.05) larger in the Proglumide 91 mm2) than in the anticida group (23 mm2). In addition, the half time of the ulcer-healing was significantly (p less than 0.05) shorter in the Proglumide treated patients (18 days and 26 days respectively). There was no significant effect of the drug on the duodenal ulcers. The spontaneous healing rate was 61% in the antacid (n = 18) and 59% in the Proglumide treated (n = 17) patients. The drug does not effect the basal and pentagastrin stimulated gastric secretion nor the serum gastrin concentration. No side effects on blood pressure, blood cell count, transaminases or blood glucose concentrations could be observed.
在一项前瞻性双盲研究中，11名男性和5名女性胃溃疡门诊患者以及28名男性和7名女性十二指肠溃疡门诊患者接受了丙谷胺（1200毫克/天）或三硅酸镁（1320毫克/天）治疗。在治疗4周前后通过内窥镜检查评估溃疡大小。接受丙谷胺治疗的患者中75%（n = 8）的胃溃疡完全愈合，而接受抗酸剂治疗的对照组中这一比例为25%（n = 8）（p<0.05；卡方检验）。丙谷胺组（91平方毫米）愈合面积显著大于抗酸剂组（23平方毫米）（p<0.05）。此外，丙谷胺治疗的患者溃疡愈合的半衰期显著缩短（p<0.05）（分别为18天和26天）。该药物对十二指肠溃疡无显著影响。抗酸剂治疗组（n = 18）的自发愈合率为61%，丙谷胺治疗组（n = 17）为59%。该药物不影响基础胃酸分泌和五肽胃泌素刺激的胃酸分泌，也不影响血清胃泌素浓度。未观察到对血压、血细胞计数、转氨酶或血糖浓度的副作用。
