Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Int J Epidemiol. 2024 Apr 11;53(3). doi: 10.1093/ije/dyae059.
Evidence on the potential association between dietary copper intake and gastric cancer (GC) is lacking. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project-an international consortium of epidemiological studies on GC.
Data from five case-control studies within the StoP Project were included (2448 cases, 4350 controls). We estimated adjusted odds ratios (ORs) and 95% CIs for the association between dietary copper intake and GC using multivariable mixed-effects logistic regression models. We also modelled the dose-response relationship between copper intake and GC using a logistic mixed-effects model with fractional polynomial.
The OR for the highest quartile of copper intake compared with the lowest one was 0.78 (95% CI: 0.63-0.95; P for trend = 0.013). Results were similar for non-cardia-type (OR: 0.72; 95% CI: 0.57-0.91), intestinal-type (OR: 0.75; 95% CI: 0.56-0.99) and other histological-type GC (OR: 0.65; 95% CI: 0.44-0.96). The dose-response analysis showed a steep decrease in ORs for modest intakes (<1 mg/day), which were subsequently steady for ≤3 mg/day (OR: 0.09; 95% CI: 0.02-0.41) and slowly increased for higher intakes.
The findings of our large study suggest that copper intake might be inversely associated with GC, although their confirmation by prospective studies is required.
关于饮食铜摄入量与胃癌（GC）之间潜在关联的证据尚不足。因此，我们旨在通过胃癌国际流行病学研究合作组织（StoP 项目）中的五个病例对照研究评估这种关联。
纳入 StoP 项目中的五个病例对照研究的数据（2448 例病例，4350 例对照）。我们使用多变量混合效应逻辑回归模型估计了饮食铜摄入量与 GC 之间的关联的调整比值比（OR）和 95%置信区间（CI）。我们还使用逻辑混合效应模型的分数多项式模型来对铜摄入量与 GC 之间的剂量-反应关系进行建模。
与最低摄入量相比，最高摄入量四分位数的 OR 为 0.78（95%CI：0.63-0.95；趋势 P 值=0.013）。非贲门型（OR：0.72；95%CI：0.57-0.91）、肠型（OR：0.75；95%CI：0.56-0.99）和其他组织学类型 GC（OR：0.65；95%CI：0.44-0.96）的结果相似。剂量-反应分析显示，适度摄入量（<1 毫克/天）的 OR 急剧下降，随后在≤3 毫克/天的摄入量保持稳定（OR：0.09；95%CI：0.02-0.41），而在更高的摄入量下则缓慢增加。
我们的大型研究结果表明，铜摄入量可能与 GC 呈负相关，尽管需要前瞻性研究来证实这一点。
