Immunologie-oncologie, Centre de recherche de l'Hôpital Maisonneuve-Rosemont, Montréal, QC, Canada.
Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, QC, Canada.
Immunol Cell Biol. 2024 Jul;102(6):441-443. doi: 10.1111/imcb.12763. Epub 2024 Apr 26.
In this article for the Highlights of 2023 Series, we discuss how various factors affect the ability of natural killer (NK) cells to fight tumors. For instance, tumor cells can hinder NK cell function by reducing surface protrusions or increasing HLA-E expression via platelets. Lower UTX protein levels in male NK cells also decrease their cytotoxicity compared with females. Fortunately, recent advancements in therapeutic approaches have emerged, including the development of a comprehensive atlas of NK cell heterogeneity within the tumor microenvironment, as well as a trispecific engager molecule that has shown promise in enhancing the anti-tumor functions of NK cells.
在本期 2023 年亮点文章中，我们将讨论各种因素如何影响自然杀伤 (NK) 细胞杀伤肿瘤的能力。例如，肿瘤细胞可以通过减少表面突起或通过血小板增加 HLA-E 的表达来阻碍 NK 细胞的功能。男性 NK 细胞中较低的 UTX 蛋白水平也会降低其与女性相比的细胞毒性。幸运的是，最近出现了一些治疗方法的进展，包括在肿瘤微环境中全面描绘 NK 细胞异质性的图谱，以及一种三特异性结合分子，该分子在增强 NK 细胞的抗肿瘤功能方面显示出了希望。
