实验室检查在风湿免疫相关不良事件评估和管理中的应用。
The Utility of Laboratory Investigations for the Assessment and Management of Rheumatic Immune Related Adverse Events.
机构信息
Division of Rheumatology, Department of Medicine, Jewish General Hospital and McGill University, 3755 Côte Ste-Catherine Road, Montreal, Quebec H3T 1E2, Canada.
Department of Rheumatology and Clinical Immunology, Amsterdam University Medical Center, VU University Medical Center (VUmc), De Boelelaan 1118, Amsterdam 1081 HZ, the Netherlands.
出版信息
Rheum Dis Clin North Am. 2024 May;50(2):181-199. doi: 10.1016/j.rdc.2024.01.003. Epub 2024 Feb 22.
Immune checkpoint inhibitors (ICIs) have greatly improved survival of several cancers with historically very poor prognosis. ICIs act by stimulating the patient's own immune system to fight cancer. Simultaneously, this immune activation can lead to immune-related adverse events (irAEs), including rheumatic manifestations (Rh-irAEs). Rh-irAEs mimic primary rheumatic diseases including arthritis, polymyalgia rheumatica, myositis, vasculitis, sarcoidosis, and sicca. This article summarizes the latest evidence regarding the utility of laboratory investigations in Rh-irAEs.
免疫检查点抑制剂 (ICIs) 极大地改善了几种预后极差的癌症的生存率。ICIs 通过刺激患者自身的免疫系统来对抗癌症。同时，这种免疫激活会导致免疫相关不良事件 (irAEs)，包括风湿表现 (Rh-irAEs)。Rh-irAEs 模仿包括关节炎、巨细胞动脉炎、肌炎、血管炎、结节病和干燥综合征在内的原发性风湿病。本文总结了实验室检查在 Rh-irAEs 中的应用的最新证据。
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