Hirschberg T, Berchtold W, Rhyner K, Gmür J
Schweiz Med Wochenschr. 1985 Dec 28;115(52):1881-5.
Clinical signs, complete blood counts and bone marrow differential counts at the time of diagnosis were investigated in 75 consecutive patients with chronic myelogenous leukemia in a study of prognostic parameters. All patients were followed until death (62 patients) or for a mean follow-up time of 69 months (13 patients). Clinical signs and hematological values were analyzed by univariate and multivariate statistical methods. The only parameter relevant to mean survival time in multivariate analysis is the percentage of bone marrow myeloblasts at diagnosis. Patients with less than 5% myeloblasts at diagnosis had a mean survival time of 48 months compared with 16 months for those with greater than or equal to 5% (p less than 0.01).
在一项关于预后参数的研究中，对75例连续性慢性粒细胞白血病患者诊断时的临床体征、全血细胞计数及骨髓分类计数进行了调查。所有患者均随访至死亡（62例）或平均随访69个月（13例）。采用单因素和多因素统计方法分析临床体征和血液学值。多因素分析中与平均生存时间相关的唯一参数是诊断时骨髓原始粒细胞的百分比。诊断时原始粒细胞少于5%的患者平均生存时间为48个月，而原始粒细胞大于或等于5%的患者为16个月（p<0.01）。
