S100B和脑源性神经营养因子对腰椎间盘突出症射频治疗的预测价值

Predictive value of S100B and brain derived neurotrophic factor for radiofrequency treatment of lumbar disc prolapse.

作者信息

Fathy Wael, Hussein Mona, Magdy Rehab, Elmoutaz Hatem, Youssef Neveen A, Abd Alla Marwa F, El Shaarawy Ahmed M, Abdelbadie Mohamed

机构信息

Department of Anesthesiology, Surgical ICU and Pain Management, Beni-Suef University, Salah Salem Street, Beni-Suef, 62511, Egypt.

Department of Neurology, Beni-Suef University, Beni-Suef, Egypt.

出版信息

BMC Anesthesiol. 2024 Apr 26;24(1):161. doi: 10.1186/s12871-024-02527-4.

DOI:10.1186/s12871-024-02527-4

PMID:38671372

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11046968/

Abstract

BACKGROUND

This work aimed to analyze serum S100B levels and brain-derived neurotrophic factor (BDNF) in patients with lumbar disc prolapse to test their predictive values concerning the therapeutic efficacy of pulsed radiofrequency.

METHODS

This prospective interventional study was carried out on 50 patients candidates for radiofrequency for treating symptomatic lumbar disc prolapse. Pain severity and functional disability were assessed using the Numeric Rating Scale (NRS) and Functional rating index (FRI) before as well as two weeks, 1, 3, and 6 months after the radiofrequency. Quantitative assessment of serum S100B level and BDNF was done for all the included patients one day before radiofrequency.

RESULTS

The scores of NRS and FRI were significantly improved at two weeks, 1, 3, and 6 months following radiofrequency (P-value < 0.001 in all comparisons). Statistically significant positive correlations were found between duration of pain, NRS, and S100B serum level before radiofrequency, and both NRS (P-value = 0.001, 0.035, < 0.001 respectively) and FRI (P-value = < 0.001, 0.009, 0.001 respectively) 6 months following radiofrequency. Whereas there were statistically significant negative correlations between BDNF serum level before radiofrequency and both NRS and FRI 6 months following radiofrequency (P-value = 0.022, 0.041 respectively). NRS and S100B serum levels before radiofrequency were found to be independent predictors of NRS 6 months following radiofrequency (P-value = 0.040. <0.001, respectively).

CONCLUSION

Serum level of S100B is a promising biomarker that can predict functional outcomes after pulsed radiofrequency in patients with lumbar disc prolapse.

摘要

背景

本研究旨在分析腰椎间盘突出症患者的血清S100B水平和脑源性神经营养因子（BDNF），以检验其对脉冲射频治疗效果的预测价值。

方法

本前瞻性干预研究对50例有症状的腰椎间盘突出症且拟行射频治疗的患者进行。在射频治疗前以及治疗后两周、1个月、3个月和6个月，使用数字评分量表（NRS）和功能评分指数（FRI）评估疼痛严重程度和功能障碍。对所有纳入患者在射频治疗前一天进行血清S100B水平和BDNF的定量评估。

结果

射频治疗后两周、1个月、3个月和6个月时，NRS和FRI评分均显著改善（所有比较的P值均<0.001）。射频治疗前疼痛持续时间、NRS与S100B血清水平之间存在统计学显著的正相关，且与射频治疗后6个月时的NRS（P值分别为0.001、0.035、<0.001）和FRI（P值分别为<0.001、0.009、0.001）也存在正相关。而射频治疗前BDNF血清水平与射频治疗后6个月时的NRS和FRI均存在统计学显著的负相关（P值分别为0.022、0.041）。发现射频治疗前的NRS和S100B血清水平是射频治疗后6个月时NRS的独立预测因素（P值分别为0.040、<0.001）。