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与II级和III级胶质瘤死亡率及疾病进展相关的重要基因

Significant Genes Associated with Mortality and Disease Progression in Grade II and III Glioma.

作者信息

Choi Bo Mi, Cheong Jin Hwan, Ryu Je Il, Won Yu Deok, Min Kyueng-Whan, Han Myung-Hoon

机构信息

Department of Neurosurgery, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri 11923, Gyeonggi-do, Republic of Korea.

Department of Pathology, Uijeongbu Eulji Medical Center, Eulji University School of Medicine, Uijeongbu 11759, Gyeonggi-do, Republic of Korea.

出版信息

Biomedicines. 2024 Apr 12;12(4):858. doi: 10.3390/biomedicines12040858.

DOI:10.3390/biomedicines12040858
PMID:38672212
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11048596/
Abstract

BACKGROUND: The Wnt/β-catenin pathway plays a critical role in the tumorigenesis and maintenance of glioma stem cells. This study aimed to evaluate significant genes associated with the Wnt/β-catenin pathway involved in mortality and disease progression in patients with grade II and III glioma, using the Cancer Genome Atlas (TCGA) database. METHODS: We obtained clinicopathological information and mRNA expression data from 515 patients with grade II and III gliomas from the TCGA database. We performed a multivariate Cox regression analysis to identify genes independently associated with glioma prognosis. RESULTS: The analysis of 34 genes involved in Wnt/β-catenin signaling demonstrated that four genes (CER1, FRAT1, FSTL1, and RPSA) related to the Wnt/β-catenin pathway were significantly associated with mortality and disease progression in patients with grade II and III glioma. We also identified additional genes related to the four significant genes of the Wnt/β-catenin pathway mentioned above. The higher expression of BMP2, RPL18A, RPL19, and RPS12 is associated with better outcomes in patients with glioma. CONCLUSIONS: Using a large-scale open database, we identified significant genes related to the Wnt/β-catenin signaling pathway associated with mortality and disease progression in patients with grade II and III gliomas.

摘要

背景：Wnt/β-连环蛋白通路在胶质瘤干细胞的肿瘤发生和维持中起关键作用。本研究旨在利用癌症基因组图谱（TCGA）数据库评估与Wnt/β-连环蛋白通路相关的、参与II级和III级胶质瘤患者死亡率和疾病进展的重要基因。 方法：我们从TCGA数据库中获取了515例II级和III级胶质瘤患者的临床病理信息和mRNA表达数据。我们进行了多变量Cox回归分析，以确定与胶质瘤预后独立相关的基因。 结果：对34个参与Wnt/β-连环蛋白信号传导的基因进行分析表明，与Wnt/β-连环蛋白通路相关的4个基因（CER1、FRAT1、FSTL1和RPSA）与II级和III级胶质瘤患者的死亡率和疾病进展显著相关。我们还鉴定了与上述Wnt/β-连环蛋白通路的4个重要基因相关的其他基因。BMP2、RPL18A、RPL19和RPS12的高表达与胶质瘤患者的较好预后相关。 结论：通过使用大规模开放数据库，我们鉴定了与II级和III级胶质瘤患者死亡率和疾病进展相关的、与Wnt/β-连环蛋白信号通路相关的重要基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/fc7f3dfa31fb/biomedicines-12-00858-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/dc307f138336/biomedicines-12-00858-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/a39de4eabf37/biomedicines-12-00858-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/881853208d54/biomedicines-12-00858-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/5aa994aa5627/biomedicines-12-00858-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/450432528551/biomedicines-12-00858-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/fc7f3dfa31fb/biomedicines-12-00858-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/dc307f138336/biomedicines-12-00858-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/a39de4eabf37/biomedicines-12-00858-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/881853208d54/biomedicines-12-00858-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/5aa994aa5627/biomedicines-12-00858-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/450432528551/biomedicines-12-00858-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a27/11048596/fc7f3dfa31fb/biomedicines-12-00858-g006.jpg

相似文献

[1]
Significant Genes Associated with Mortality and Disease Progression in Grade II and III Glioma.

Biomedicines. 2024-4-12

[2]
DKK3 expression is associated with immunosuppression and poor prognosis in glioblastoma, in contrast to lower-grade gliomas.

BMC Neurol. 2023-5-6

[3]
The expressions of Wnt/β-catenin pathway-related components in brainstem gliomas.

Can J Neurol Sci. 2013-5

[4]
Bmal1 regulates the stemness and tumorigenesis of gliomas with the Wnt/β-catenin signaling pathway.

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[5]
The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner.

Oncotarget. 2017-4-18

[6]
CUX1 Facilitates the Development of Oncogenic Properties Activating Wnt/β-Catenin Signaling Pathway in Glioma.

Front Mol Biosci. 2021-8-6

[7]
TROAP regulates cell cycle and promotes tumor progression through Wnt/β-Catenin signaling pathway in glioma cells.

CNS Neurosci Ther. 2021-6-2

[8]
Downregulation of SFRP2 facilitates cancer stemness and radioresistance of glioma cells via activating Wnt/β-catenin signaling.

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[9]
FRAT1 Enhances the Proliferation and Tumorigenesis of CD133Nestin Glioma Stem Cells In Vitro and In Vivo.

J Cancer. 2020-2-10

[10]
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Ideggyogy Sz. 2021-9-30

引用本文的文献

[1]
Integrated single-cell and transcriptomic analysis of bone marrow-derived metastatic neuroblastoma reveals molecular mechanisms of metabolic reprogramming.

Sci Rep. 2025-8-5

本文引用的文献

[1]
DKK3 expression is associated with immunosuppression and poor prognosis in glioblastoma, in contrast to lower-grade gliomas.

BMC Neurol. 2023-5-6

[2]
Reclassification of TCGA Diffuse Glioma Profiles Linked to Transcriptomic, Epigenetic, Genomic and Clinical Data, According to the 2021 WHO CNS Tumor Classification.

Int J Mol Sci. 2022-12-21

[3]
Identification of prognosis-related gene features in low-grade glioma based on ssGSEA.

Front Oncol. 2022-12-14

[4]
Identification of genes from ten oncogenic pathways associated with mortality and disease progression in glioblastoma.

Front Oncol. 2022-8-10

[5]
High DKK3 expression related to immunosuppression was associated with poor prognosis in glioblastoma: machine learning approach.

Cancer Immunol Immunother. 2022-12

[6]
Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo.

J Biol Chem. 2022-7

[7]
Surveillance imaging frequency in adult patients with lower-grade (WHO Grade 2 and 3) gliomas.

Neuro Oncol. 2022-7-1

[8]
FRAT1 promotes the angiogenic properties of human glioblastoma cells via VEGFA.

Mol Med Rep. 2022-3

[9]
FSTL1 Secreted by Activated Fibroblasts Promotes Hepatocellular Carcinoma Metastasis and Stemness.

Cancer Res. 2021-11-15

[10]
Prediction and analysis of hub genes between glioblastoma and low-grade glioma using bioinformatics analysis.

Medicine (Baltimore). 2021-1-22

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