Brown Savannah R, Vomhof-DeKrey Emilie E
Department of Pathology, School of Medicine and the Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Department of Surgery, School of Medicine and the Health Sciences, University of North Dakota, Grand Forks, ND 58202, USA.
Biomedicines. 2024 Apr 18;12(4):895. doi: 10.3390/biomedicines12040895.
Breast cancer receives the most funding when compared to any other cancer type, according to a global study conducted by . Nevertheless, this malignancy remains the most diagnosed cancer among women and relies heavily on a neoadjuvant treatment regimen of chemotherapy and targeted therapy. After standard treatment, 25-30% of breast cancer patients still develop disease recurrence and must undergo cytoreductive debulking surgery followed by intensive chemotherapy. An array of targeted therapies are currently being utilized and developed to alleviate negative side effects, eradicate cancer growth, and diminish disease recurrence. Immunotherapy is a promising cancer therapy that upregulates one's immune system to stimulate a therapeutic effect and is utilized for cancer management among other ailments such as immunodeficiencies, hypersensitivity reactions, autoimmune diseases, inflammatory disorders, tissue and organ transplantation, and infectious diseases. This review highlights the five primary subtypes of breast cancer, provides a brief history of immunotherapy, evaluates the current landscape of treating breast cancer with immunotherapy, analyzes selected ongoing or recently completed immunotherapy clinical trials for hormone receptor-positive, HER2-enriched, and triple-negative breast cancer, and examines future trends for the treatment of breast cancer with immunotherapeutic techniques. This review provides a formal summary categorized by breast cancer subtype rather than types of immunotherapeutic treatment.
根据[机构名称]开展的一项全球研究，与其他任何癌症类型相比，乳腺癌获得的资金最多。然而，这种恶性肿瘤仍是女性中诊断最多的癌症，并且严重依赖化疗和靶向治疗的新辅助治疗方案。标准治疗后，25%至30%的乳腺癌患者仍会出现疾病复发，必须接受减瘤手术，随后进行强化化疗。目前正在使用和研发一系列靶向治疗方法，以减轻负面副作用、根除癌症生长并减少疾病复发。免疫疗法是一种很有前景的癌症治疗方法，它可上调人体免疫系统以刺激治疗效果，并且用于癌症治疗以及免疫缺陷、过敏反应、自身免疫性疾病、炎症性疾病、组织和器官移植及传染病等其他疾病的治疗。本综述重点介绍了乳腺癌的五种主要亚型，简要介绍了免疫疗法的历史，评估了目前用免疫疗法治疗乳腺癌的现状，分析了针对激素受体阳性、HER2富集型和三阴性乳腺癌正在进行或最近完成的免疫疗法临床试验，并探讨了用免疫治疗技术治疗乳腺癌的未来趋势。本综述提供了按乳腺癌亚型而非免疫治疗类型分类的正式总结。
