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评估绝对中性粒细胞、淋巴细胞和血小板计数及其比值作为纤维化前期和明显骨髓纤维化患者血栓形成风险预测指标的价值。

Evaluation of Absolute Neutrophil, Lymphocyte and Platelet Count and Their Ratios as Predictors of Thrombotic Risk in Patients with Prefibrotic and Overt Myelofibrosis.

作者信息

Lucijanic Marko, Krecak Ivan, Soric Ena, Sabljic Anica, Galusic Davor, Holik Hrvoje, Perisa Vlatka, Moric Peric Martina, Zekanovic Ivan, Budimir Josipa, Kusec Rajko

机构信息

Hematology Department, University Hospital Dubrava, Av. Gojka Suska 6, 10000 Zagreb, Croatia.

School of Medicine, University of Zagreb, Ul. Salata 3, 10000 Zagreb, Croatia.

出版信息

Life (Basel). 2024 Apr 17;14(4):523. doi: 10.3390/life14040523.

DOI:10.3390/life14040523

PMID:38672793

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11051164/

Abstract

AIM

To investigate the prognostic contribution of absolute neutrophil (ANC), lymphocyte (ALC), platelet count and their ratios, neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR), to thrombotic risk in patients with prefibrotic and overt fibrotic myelofibrosis (MF).

METHODS

We retrospectively analyzed a cohort of 256 patients with prefibrotic (85 patients) and overt fibrotic MF (171 patients) treated in six Croatian hematological centers.

RESULTS

Prefibrotic compared to overt fibrotic MF patients presented with significantly higher ALC, platelet count and PLR, and experienced longer time to thrombosis (TTT). Among prefibrotic patients, ANC > 8.33 × 10/L (HR 13.08, = 0.036), ALC > 2.58 × 10/L (HR 20.63, = 0.049) and platelet count > 752 × 10/L (HR 10.5, = 0.043) remained independently associated with shorter TTT. Among overt fibrotic patients, ANC > 8.8 × 10/L (HR 4.49, = 0.004), ALC ≤ 1.43 × 10/L (HR 4.15, = 0.003), platelet count ≤ 385 × 10/L (HR 4.68, = 0.004) and chronic kidney disease (HR 9.07, < 0.001) remained independently associated with shorter TTT.

CONCLUSIONS

Prognostic properties of ANC, ALC and platelet count are mutually independent and exceed those of NLR and PLR regarding thrombotic risk stratification. ALC and platelet count associate in opposite directions with thrombotic risk in prefibrotic and overt fibrotic MF patients.

摘要

目的

探讨绝对中性粒细胞计数（ANC）、淋巴细胞计数（ALC）、血小板计数及其比值，即中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR），对纤维化前期和明显纤维化的骨髓纤维化（MF）患者血栓形成风险的预后影响。

方法

我们回顾性分析了在克罗地亚六个血液学中心接受治疗的256例纤维化前期（85例）和明显纤维化MF（171例）患者的队列。

结果

与明显纤维化MF患者相比，纤维化前期患者的ALC、血小板计数和PLR显著更高，血栓形成时间（TTT）更长。在纤维化前期患者中，ANC>8.33×10⁹/L（HR 13.08，P = 0.036）、ALC>2.58×10⁹/L（HR 20.63，P = 0.049）和血小板计数>752×10⁹/L（HR 10.5，P = 0.043）与较短的TTT独立相关。在明显纤维化患者中，ANC>8.8×10⁹/L（HR 4.49，P = 0.004）、ALC≤1.43×10⁹/L（HR 4.15，P = 0.003）、血小板计数≤385×10⁹/L（HR 4.68，P = 0.004）和慢性肾脏病（HR 9.07，P<0.001）与较短的TTT独立相关。