Tallini Luciana R, Manfredini Giulia, Rodríguez-Escobar María Lenny, Ríos Segundo, Martínez-Francés Vanessa, Feresin Gabriela E, Borges Warley de Souza, Bastida Jaume, Viladomat Francesc, Torras-Claveria Laura
Departament de Biologia, Sanitat i Medi Ambient, Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028 Barcelona, Spain.
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga 2752, Porto Alegre 90610-000, RS, Brazil.
Life (Basel). 2024 Apr 22;14(4):536. doi: 10.3390/life14040536.
L. is a renowned plant genus with a notable center of diversity and is primarily located in the Mediterranean region. These plants are widely recognized for their ornamental value, owing to the beauty of their flowers; nonetheless, they also hold pharmacological importance. In Europe, pharmaceutical companies usually use the bulbs of cv. Carlton to extract galanthamine, which is one of the few medications approved by the FDA for the palliative treatment of mild-to-moderate symptoms of Alzheimer's disease. The purpose of this study was to evaluate the potential of these plants in Alzheimer's disease. The alkaloid extract from the leaves of different species of was obtained by an acid-base extraction work-up -procedure. The biological potential of the samples was carried out by evaluating their ability to inhibit the enzymes acetyl- and butyrylcholinesterase (AChE and BuChE, respectively). The species exhibited the best inhibition values against AChE, with IC values of 0.75 ± 0.03 µg·mL, while was the most active against BuChE, with IC values of 11.72 ± 1.15 µg·mL.
L.是一个著名的植物属，拥有显著的多样性中心，主要分布在地中海地区。这些植物因其花朵的美丽而具有很高的观赏价值，然而，它们也具有重要的药理学意义。在欧洲，制药公司通常使用cv. Carlton的鳞茎来提取加兰他敏，这是美国食品药品监督管理局（FDA）批准的用于姑息治疗轻度至中度阿尔茨海默病症状的少数药物之一。本研究的目的是评估这些植物在阿尔茨海默病治疗中的潜力。通过酸碱提取后处理程序从不同物种的叶子中获得生物碱提取物。通过评估样品抑制乙酰胆碱酯酶和丁酰胆碱酯酶（分别为AChE和BuChE）的能力来测定样品的生物学潜力。该物种对AChE表现出最佳的抑制值，IC值为0.75±0.03μg·mL，而对BuChE最具活性，IC值为11.72±1.15μg·mL。
