Kwon Mi Jung, Kim Jwa-Kyung, Kim Min-Jeong, Yoo Dae Myoung, Lee Na-Eun, Han Kyeong Min, Kim Nan Young, Kang Ho Suk, Choi Hyo Geun, Kim Eun Soo
Department of Pathology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
Laboratory of Brain and Cognitive Sciences for Convergence Medicine, Hallym University College of Medicine, Anyang 14068, Republic of Korea.
J Pers Med. 2024 Mar 28;14(4):356. doi: 10.3390/jpm14040356.
While headaches frequently occur in individuals with chronic kidney disease (CKD), there are few statistical evaluations of their connection to migraines in population-based studies. In this nationwide longitudinal follow-up study of Korean health examination data (2002-2019), a total of 15,443 participants with CKD and 61,772 matched controls were enrolled. We applied overlap-weighted Cox proportional hazard regression models to assess hazard ratios, examining the correlation between CKD and the development of migraines. After accounting for various factors, we observed a modest reduction of approximately 11% in the likelihood of migraine occurrence among CKD patients (95% confidence intervals = 0.81-0.97) during the 16-year monitoring period. Subgroup analysis revealed a significant association among specific demographic and health conditions, including individuals aged 70 or older, females, overweight individuals, nonsmokers, and those without hypertension or diabetes. Our research may indicate a potential relationship between CKD and the onset of migraines in Korean adults, suggesting a slight reduction in the probability of the occurrence of migraines among those with CKD. These findings emphasize the need for attentive follow-up and preventive management in individuals without the identified protective factors, particularly in male CKD patients under the age of 70 with hypertension.
虽然慢性肾脏病（CKD）患者经常出现头痛症状，但在基于人群的研究中，对其与偏头痛之间关联的统计评估却很少。在这项对韩国健康检查数据（2002 - 2019年）进行的全国性纵向随访研究中，共纳入了15443名CKD参与者和61772名匹配的对照组。我们应用重叠加权Cox比例风险回归模型来评估风险比，研究CKD与偏头痛发病之间的相关性。在考虑各种因素后，我们观察到在16年的监测期内，CKD患者发生偏头痛的可能性适度降低了约11%（95%置信区间 = 0.81 - 0.97）。亚组分析揭示了特定人口统计学和健康状况之间的显著关联，包括70岁及以上的个体、女性、超重个体、不吸烟者以及没有高血压或糖尿病的个体。我们的研究可能表明韩国成年人中CKD与偏头痛发作之间存在潜在关系，提示CKD患者偏头痛发生的概率略有降低。这些发现强调了对没有已确定保护因素的个体，特别是70岁以下患有高血压的男性CKD患者，需要进行密切随访和预防性管理。
