Kastner Tom, Frohberg Florian, Hesse Judith, Wolfarth Bernd, Wuestenfeld Jan C
Institute for Applied Training Science, Marschnerstrasse 29, 04109 Leipzig, Germany.
Department of Sports Medicine, Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany.
J Clin Med. 2024 Apr 18;13(8):2335. doi: 10.3390/jcm13082335.
Troponin I and T are biomarkers to diagnose myocardial infarction and damage. Studies indicate that strenuous physical activity can cause transient increases in these troponin levels, typically considered physiological. However, current data show differences in the exercise-induced increase in troponin I and T in elite athletes. This prospective clinical study aimed to determine troponin I and T levels in 36 top cross-country skiers of the German national team (18 male, 18 female) after a standardized competition load over two days. All study participants underwent a comprehensive sports medical and cardiological evaluation, including ECG and echocardiography. A multivariable regression analysis was utilized to identify possible predictors of increased troponin I levels. Only three male athletes (8.1%) showed an isolated increase in Troponin I (Ø 112.49 ng/L, cut off < 45.2 ng/L), while no increase in troponin T in the study population was detected. The analysis suggested several potential predictors for increased troponin I levels, such as height, weight, weekly training hours, and indications of an enlarged sports heart, though none achieved statistical significance. Knowing the different exercise-induced detectability of the various troponins in the clinical setting is essential.
肌钙蛋白I和T是诊断心肌梗死和心肌损伤的生物标志物。研究表明,剧烈的体育活动可导致这些肌钙蛋白水平短暂升高,通常认为这是生理性的。然而,目前的数据显示,精英运动员运动诱导的肌钙蛋白I和T升高存在差异。这项前瞻性临床研究旨在测定德国国家队36名顶级越野滑雪运动员(18名男性,18名女性)在两天标准化比赛负荷后的肌钙蛋白I和T水平。所有研究参与者都接受了全面的运动医学和心脏病学评估,包括心电图和超声心动图检查。采用多变量回归分析来确定肌钙蛋白I水平升高的可能预测因素。只有三名男性运动员(8.1%)出现了孤立的肌钙蛋白I升高(平均值112.49 ng/L,临界值<45.2 ng/L),而在研究人群中未检测到肌钙蛋白T升高。分析表明了几个肌钙蛋白I水平升高的潜在预测因素,如身高、体重、每周训练时长以及运动性心脏扩大的迹象,尽管这些因素均未达到统计学显著性。了解临床环境中不同肌钙蛋白运动诱导的可检测性差异至关重要。