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心肌肌钙蛋白血清浓度检测不仅对急性心血管事件的诊断有用。

Cardiac Troponin Serum Concentration Measurement Is Useful Not Only in the Diagnosis of Acute Cardiovascular Events.

作者信息

Jakubiak Grzegorz K

机构信息

Department and Clinic of Internal Medicine, Angiology, and Physical Medicine, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Batorego 15 St., 41-902 Bytom, Poland.

出版信息

J Pers Med. 2024 Feb 21;14(3):230. doi: 10.3390/jpm14030230.

Abstract

Cardiac troponin serum concentration is the primary marker used for the diagnosis of acute coronary syndrome. Moreover, the measurement of cardiac troponin concentration is important for risk stratification in patients with pulmonary embolism. The cardiac troponin level is also a general marker of myocardial damage, regardless of etiology. The purpose of this study is to conduct a literature review and present the most important information regarding the current state of knowledge on the cardiac troponin serum concentration in patients with chronic cardiovascular disease (CVD), as well as on the relationships between cardiac troponin serum concentration and features of subclinical cardiovascular dysfunction. According to research conducted to date, patients with CVDs, such as chronic coronary syndrome, chronic lower extremities' ischemia, and cerebrovascular disease, are characterized by higher cardiac troponin concentrations than people without a CVD. Moreover, the literature data indicate that the concentration of cardiac troponin is correlated with markers of subclinical dysfunction of the cardiovascular system, such as the intima-media thickness, pulse wave velocity, ankle-brachial index, coronary artery calcium index (the Agatston score), and flow-mediated dilation. However, further research is needed in various patient subpopulations and in different clinical contexts.

摘要

心肌肌钙蛋白血清浓度是用于诊断急性冠状动脉综合征的主要标志物。此外,测定心肌肌钙蛋白浓度对于肺栓塞患者的危险分层很重要。无论病因如何,心肌肌钙蛋白水平也是心肌损伤的一个通用标志物。本研究的目的是进行文献综述,并呈现关于慢性心血管疾病(CVD)患者心肌肌钙蛋白血清浓度的当前知识状态,以及心肌肌钙蛋白血清浓度与亚临床心血管功能障碍特征之间关系的最重要信息。根据迄今为止进行的研究,患有慢性冠状动脉综合征、慢性下肢缺血和脑血管疾病等心血管疾病的患者,其心肌肌钙蛋白浓度高于无心血管疾病的人。此外,文献数据表明,心肌肌钙蛋白浓度与心血管系统亚临床功能障碍的标志物相关,如内膜中层厚度、脉搏波速度、踝臂指数、冠状动脉钙化指数(阿加斯顿评分)和血流介导的扩张。然而,需要在不同患者亚群和不同临床背景下进行进一步研究。

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