Dec Paweł, Żyłka Małgorzata, Burszewski Piotr, Modrzejewski Andrzej, Pawlik Andrzej
Plastic and Reconstructive Surgery Department, 109 Military Hospital, 71-422 Szczecin, Poland.
Department of Surgery, Pomeranian Medical University, 71-422 Szczecin, Poland.
Int J Mol Sci. 2024 Apr 19;25(8):4498. doi: 10.3390/ijms25084498.
Due to their function, tendons are exposed to acute injuries. This type of damage to the musculoskeletal system represents a challenge for clinicians when natural regeneration and treatment methods do not produce the expected results. Currently, treatment is long and associated with long-term complications. In this review, we discuss the use of stem cells in the treatment of tendons, including how to induce appropriate cell differentiation based on gene therapy, growth factors, tissue engineering, proteins involved in regenerative process, drugs and three-dimensional (3D) structures. A multidirectional approach as well as the incorporation of novel components of the therapy will improve the techniques used and benefit patients with tendon injuries in the future.
由于其功能，肌腱容易遭受急性损伤。当自然再生和治疗方法未产生预期效果时，这种对肌肉骨骼系统的损伤类型对临床医生而言是一项挑战。目前，治疗过程漫长且伴有长期并发症。在本综述中，我们讨论了干细胞在肌腱治疗中的应用，包括如何基于基因治疗、生长因子、组织工程、再生过程中涉及的蛋白质、药物和三维（3D）结构来诱导适当的细胞分化。一种多方向的方法以及治疗中新型成分的纳入将改进所使用的技术，并在未来使肌腱损伤患者受益。
